城西大学機関リポジトリJURAAbsorption Kinetics of Subcutaneously Administered Ceftazidime in Hypoperfused Guinea Pigs

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Absorption Kinetics of Subcutaneously Administered Ceftazidime in Hypoperfused Guinea Pigs

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ID	JOS-j.curtheres.2014.09.006
著者：名前	海老原, 毅/大島, 新司/沖田, 光良/椎名, さゆみ/根岸, 彰生/大原, 厚祐/大嶋, 繁/岩崎, 博之/米山, 明/北住, 映二/小林, 大介
著者：別形式	Ebihara, Tsuyoshi / Oshima, Shinji / Okita, Mitsuyoshi / Shiina, Sayumi / Negishi, Akio / Ohara, Kousuke / Ohshima, Shigeru / Iwasaki, Hiroyuki / Yoneyama, Akira / Kitazumi, Eiji / Kobayashi, Daisuke
著者：カナ	エビハラ, ツヨシ/オオシマ, シンジ/オキタ, ミツヨシ/シイナ, サユミ/ネギシ, アキオ/オオハラ, コウスケ/オオシマ, シゲル/イワサキ, ヒロユキ/ヨネヤマ, アキラ/キタズミ, エイジ/コバヤシ, ダイスケ
著者：所属	心身障害児総合医療療育センター薬剤科 / 城西大学薬学部薬剤作用解析学講座 / 城西大学薬学部薬剤作用解析学講座 / 城西大学薬学部薬剤作用解析学講座 / 城西大学薬学部薬剤作用解析学講座 / 城西大学薬学部薬剤作用解析学講座 / 城西大学薬学部薬剤作用解析学講座 / 心身障害児総合医療療育センター小児科 / 心身障害児総合医療療育センター小児科 / 心身障害児総合医療療育センター小児科 / 城西大学薬学部薬剤作用解析学講座
著者：所属(別形式）	National Rehabilitation Center for Children with Disabilities, Department of Pharmacy Services / Josai University, Faculty of Pharmaceutical Sciences, Department of Analytical Pharmaceutics and Informatics / Josai University, Faculty of Pharmaceutical Sciences, Department of Analytical Pharmaceutics and Informatics / Josai University, Faculty of Pharmaceutical Sciences, Department of Analytical Pharmaceutics and Informatics / Josai University, Faculty of Pharmaceutical Sciences, Department of Analytical Pharmaceutics and Informatics / Josai University, Faculty of Pharmaceutical Sciences, Department of Analytical Pharmaceutics and Informatics / Josai University, Faculty of Pharmaceutical Sciences, Department of Analytical Pharmaceutics and Informatics / National Rehabilitation Center for Children with Disabilities, Department of Pediatrics / National Rehabilitation Center for Children with Disabilities, Department of Pediatrics / National Rehabilitation Center for Children with Disabilities, Department of Pediatrics / Josai University, Faculty of Pharmaceutical Sciences, Department of Analytical Pharmaceutics and Informatics
著者版フラグ	publisher
出版者	Elsevier
NCID	AA1152517X
冊子ISSN	0011393X
電子ISSN	0011393X
掲載誌名	Current Therapeutic Research
巻	77
刊行年月	2014-12
開始ページ	7
終了ページ	13
コンテンツ作成日	2014-09-19
コンテンツ登録日	2015-02-13
識別番号：DOI	info:doi/10.1016/j.curtheres.2014.09.006
識別番号：DOI（リンク）	http://dx.doi.org/10.1016/j.curtheres.2014.09.006
抄録	Background: Pneumonia is the most common cause of death in patients with severe motor and intellectual disabilities (SMID), and intravenous ceftazidime (CAZ) is a widely used treatment for such infections. However, intravenous administration in patients with SMID may be difficult because of insufficient vascular development. Objectives: The aim of our study was to determine the feasibility of subcutaneous drug administration by mentholated warm compresses (WMCs) as an alternative delivery method for ceftazidime in patients with SMID. Methods: CAZ was subcutaneously administered to the abdominal region of naphazoline-treated hypoperfused guinea pigs, which were used as a hemodynamic model of patients with SMID. MWCs or warm compresses (WCs) were applied to the injection site to increase blood flow. We calculated the cumulative CAZ absorption over time by using the deconvolution method. Results: Application of MWCs or WCs increased blood flow at the administration site and increased CAZ plasma levels. Application of MWCs or WCs after subcutaneous CAZ injection led to higher CAZ plasma levels than the mutant prevention concentration for a longer period than was observed for CAZ administration without the application of MWCs or WCs. Conclusions: The application of MWCs or WCs enhanced subcutaneous CAZ absorption by increasing blood flow. MWCs and WCs are considered to be safe and routine methods to induce defecation after surgery on the digestive system; thus, the combination of these methods and subcutaneous CAZ administration is a potential method for treating pneumonia in patients with SMID.
キーワード	blood flow/ceftazidime/mentholated warmcompress/severemotorandintellectualdisabilities/subcutaneous absorption
注記	Open Access. Original Research.
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	c2014.The Authoes. Published by Elsevier Inc. This is an open access article under the CCBY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/).
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