ID | JOS-j.jnutbio.2009.02.013 |
著者:名前 | |
著者:別形式 | Hirako, Satoshi / Kim, Hyoun-Ju / Arai, Takeshi / Chiba, Hiroshige / Matsumoto, Akiyo |
著者:カナ | |
著者:所属 | 城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 / 城西大学大学院薬学研究科 / 城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 |
著者:所属(別形式) | Josai University, Faculty of Pharmaceutical Sciences, Department of Clinical Dietetics & Human Nutrition / Josai University, Faculty of Pharmaceutical Sciences, Department of Clinical Dietetics & Human Nutrition / Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences, Department of Clinical Dietetics & Human Nutrition / Josai University, Faculty of Pharmaceutical Sciences, Department of Clinical Dietetics & Human Nutrition |
著者版フラグ | author |
出版者 | Elsevier |
NCID | AA10748929 |
冊子ISSN | 09552863 |
電子ISSN | 09552863 |
掲載誌名 | |
巻 | 21 |
号 | 7 |
刊行年月 | 2010-07 |
開始ページ | 573 |
終了ページ | 579 |
コンテンツ作成日 | 2008-12-24 |
コンテンツ修正日 | 2009-02-13 |
コンテンツ登録日 | 2009-02-20 |
識別番号:DOI | info:doi/10.1016/j.jnutbio.2009.02.013 |
識別番号:DOI(リンク) | |
抄録 | Although cholesterol plays various important roles in the body, when overconsumed, it causes atherosclerosis and results in ischemic heart disease. On the other hand, dietary fish oils contain n-3 fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which prevent ischemic heart disease. This effect of n-3 fatty acids mainly results from the combined effects of inhibiting lipogenesis via a decrease of the mature form of sterol regulatory element-binding proteins (SREBPs) and stimulating fatty acid oxidation, via peroxisome proliferator-activator receptor (PPAR) α activation in the liver. In this study, we examined the interactive effects on lipid metabolism of dietary 2% cholesterol (w/w) and 20 or 50% energy fish oil. In a safflower oil diet with 2% cholesterol, hepatic lipids accumulated. On the other hand, hepatic lipids did not accumulate in the fish oil diets with cholesterol. Furthermore, in the groups with fish oil energy ratios of 20%, the negative feedback control of cholesterol affected SREBP-2, and the actions of fish oil and cholesterol were equivalent, but this was not observed in the cases with fish oil energy ratios of 50%. The results of this study suggest that differences in lipid accumulation in the body are due to differences in lipid source and energy ratios which differentially impact the control of transcription factors by cholesterol. |
目次 | 1. Introduction2. Materials and methods2.1. Diet compositions2.2. Animals2.3. Collection of blood and tissue samples2.4. Measurement of lipid in plasma and liver2.5. Measurement of mRNA in the liver2.6. Statistical analysis3. Results3.1. Body weight and tissue weight3.2. Liver appearance and tissue histology3.3. Assessment of abdominal fat tissues using X-ray CT3.4. Plasma and hepatic lipid levels3.5. Hepatic expression levels of genes involved in lipid metabolism4. DiscussionReferences |
キーワード | |
注記 | Research Articles |
言語 | eng |
資源タイプ | text |
ジャンル | |
フォーマット | application/pdf |
このアイテムを表示する:本文(pdf) | ( 853.4KB) ダウンロード回数: 回 |
このアイテムを表示する:URI | |