| ID | JOS-j.plefa.2016.10.007 |
| 著者：名前 | |
| 著者：別形式 | Iizuka, Yuzuru / Kim, Hyonju / Izawa, Takuya / Sakurai, Koji / Hirako, Satoshi / Wada, Masahiro / Matsumoto, Akiyo |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 / 人間総合科学大学人間科学部健康栄養学科 / 城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmaceutical Sciences, Department of Clinical Dietetics & Human Nutrition / Josai University, Faculty of Pharmaceutical Sciences, Department of Clinical Dietetics & Human Nutrition / Josai University, Faculty of Pharmaceutical Sciences, Department of Clinical Dietetics & Human Nutrition /Josai University, Faculty of Pharmaceutical Sciences, Department of Clinical Dietetics & Human Nutrition / University of Human Arts and Sciences, Department of Health and Nutrition / Josai University, Faculty of Pharmaceutical Sciences, Department of Clinical Dietetics & Human Nutrition / Josai University, Faculty of Pharmaceutical Sciences, Department of Clinical Dietetics & Human Nutrition |
| 著者版フラグ | author |
| 出版地 | Amsterdam |
| 出版者 | Elsevier |
| NCID | AA10691708 |
| 冊子ISSN | 09523278 |
| 電子ISSN | 15322823 |
| 掲載誌名 | |
| 巻 | 115 |
| 刊行年月 | 2016-12 |
| 開始ページ | 53 |
| 終了ページ | 59 |
| コンテンツ作成日 | 2016-04-05 |
| コンテンツ修正日 | 2016-10-17 |
| コンテンツ登録日 | 2018-01-18 |
| 識別番号：DOI | info:doi/10.1016/j.plefa.2016.10.007 |
| 識別番号：DOI（リンク） | |
| PubMed番号 | 27914514 |
| 抄録 | n-3 Polyunsaturated fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have protective effects against the pancreatic β-cell dysfunction through several mechanisms. Thiazolidines are insulin sensitizers and are used in treating patients with type 2 diabetes. Our previous study demonstrated that a combination of fish oil, which is rich with EPA and DHA, and pioglitazone exerts beneficial effects on obesity and diabetes through their actions on the liver and adipose tissue. However, it remains largely unknown whether such combination therapy affects the pancreas. To answer this question, KK mice, which serve as a model for obesity and type 2 diabetes, were treated for 8 weeks with fish oil and pioglitazone. The combined regimen suppressed pancreatic islet hypertrophy (mean islet area decreased by an average of 49% vs. control) compared with mice treated with fish oil or pioglitazone alone (decreased by an average of 21% and 32% vs. control, respectively). Compared with the controls, individual or combined treatment significantly increased the percentage of β-cell area in the pancreatic islets, significantly decreased endoplasmic reticulum stress, and reduced the percentage of apoptotic cell death in the pancreatic islets. These findings suggest that fish oil and/or pioglitazone prevents β-cell dysfunction by improving the insulin resistance and decreasing the ER stress. |
| キーワード | |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © 2016 Elsevier Ltd. |
| このアイテムを表示する：本文(pdf) |  ( 864.4KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
