| ID | JOS-j.rinphs.2013.10.002 |
| 著者：名前 | |
| 著者：別形式 | Inoue, Yutaka / Maeda, Rikimaru / Furuya, Kayoko / Murata, Isamu / Kimura, Masayuki / Kanamoto, Ikuo |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmaceutical Science, Laboratory of drug Safety Management / Josai University, Faculty of Pharmaceutical Science, Laboratory of drug Safety Management / Josai University, Faculty of Pharmaceutical Science, Laboratory of drug Safety Management / Josai University, Faculty of Pharmaceutical Science, Laboratory of drug Safety Management / Josai University, Faculty of Pharmaceutical Science, Laboratory of drug Safety Management / Josai University, Faculty of Pharmaceutical Science, Laboratory of drug Safety Management |
| 著者版フラグ | publisher |
| 出版地 | Amsterdam |
| 出版者 | Elsevier B.V. |
| 冊子ISSN | 22112863 |
| 電子ISSN | 22113517 |
| 掲載誌名 | |
| 巻 | 3 |
| 刊行年月 | 2013 |
| 開始ページ | 15 |
| 終了ページ | 19 |
| コンテンツ作成日 | 2013-10-30 |
| コンテンツ登録日 | 2014-04-06 |
| 識別番号：DOI | info:doi/10.1016/j.rinphs.2013.10.002 |
| 識別番号：DOI（リンク） | |
| 抄録 | The purpose of this study was to examine the physicochemical properties of TA ointments and conduct a human sensory test to assess the properties of those ointments. Physicochemical assessment was done via near-infrared (NIR) absorption spectroscopy, measurement of water content, microscopy, and measurement of viscoelasticity. The human sensory test examined 5 aspects (texture, cohesiveness, spreadability, smell, and feel). Three TA ointments were used: TA-A, a brand-name preparation, and TA-B and TA-C, two generics. The sensory test revealed significant differences between TA-A and TA-B and TA-C in terms of cohesiveness and spreadability. Significant differences between TA-A and TA-C and between TA-B and TA-C in terms of feel were noted. Microscopic examination revealed that TA-C had good dispersibility while TA-A and TA-B produced crystallization. NIR spectroscopy revealed differences in absorption spectra attributed to oil and water content in TAA, TA-B, and TA-C. Measurement of water content indicated water content of 0.06 ± 0.02% for TA-A, 0.08 ± 0.08% for TA-B, and 36.7 ± 1.19% for TA-C. Assessment of viscoelasticity indicated that stress decreased for all 3 ointments at 35?°C compared to that at 25?°C. TA-A and TA-B were found to have a higher percent decrease in stress than was TA-C. These findings indicate that differences in the types and content of additives caused differences in the physicochemical properties of individual ointments. In addition, differences in physicochemical properties presumably resulted in the close correlation between cohesiveness and spreadability in the sensory test. |
| キーワード | |
| 注記 | Results in Pharma Sciences is an online-only, open access journal publishing peer reviewed research from all areas of pharmaceutics and pharmaceutical sciences. |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright c 2013 The Authors |
| このアイテムを表示する：本文(pdf) |  ( 476.1KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
