| ID | JOS-j.taap.2017.05.009 |
| 著者：名前 | 杉野, 雅浩/ 畑中, 朋美/ 藤堂, 浩明/ 増茂, 裕子/ 鈴木, 貴雅/ 小林, 美穂/ 細谷, 治/ 神野, 透人/ 從二, 和彦/ 杉林, 堅次 |
| 著者：別形式 | Sugino, Masahiro / Hatanaka, Tomomi / Todo, Hiroaki / Mashimo, Yuko / Suzuki, Takamasa / Kobayashi, Miho / Hosoya, Osamu / Jinno, Hideto / Juni, Kazuhiko / Sugibayashi, Kenji |
| 著者：カナ | スギノ, マサヒロ/ ハタナカ, トモミ/ トウドウ, ヒロアキ/ マシモ, ユウコ/ スズキ, タカマサ/ コバヤシ, ミホ/ ホソヤ, オサム/ ジンノ, ヒデト/ ジュウニ, カズヒコ/ スギバヤシ, ケンジ |
| 著者：所属 | 城西大学薬学部 / 東海大学医学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 名城大学 薬学部 / 城西大学薬学部 / 城西大学薬学部 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmaceutical Sciences / Tokai University School of Medicine / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Meijo University, Faculty of Pharmacy / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences |
| 著者版フラグ | author |
| 出版地 | Amsterdam |
| 出版者 | Elsevier |
| 冊子ISSN | 0041008X |
| 電子ISSN | 10960333 |
| 掲載誌名 | |
| 巻 | 328 |
| 刊行年月 | 2017-08 |
| 開始ページ | 10 |
| 終了ページ | 17 |
| コンテンツ作成日 | 2017-02-03 |
| コンテンツ修正日 | 2017-05-11 |
| コンテンツ登録日 | 2018-07-26 |
| 識別番号：DOI | info:doi/10.1016/j.taap.2017.05.009 |
| 識別番号：DOI（リンク） | |
| PubMed番号 | 28506834 |
| 抄録 | Phthalates, known as reproductive toxicants and endocrine disruptors, are widely used as plasticizers in polyvinyl chloride products. The present study was conducted for risk identification of dermal exposure to phthalates. When dibutyl phthalate was applied to the skin of hairless rats and humans, only monobutyl phthalate appeared through the skin, and the permeability of the skin was higher than that after the application of the monoester directly. The inhibition of skin esterases made the skin impermeable to the metabolite following dermal exposure to dibutyl ester, whereas removal of the stratum corneum from the skin did not change the skin permeation behavior. Similar phenomena were observed for benzyl butyl phthalate. The skin permeability of monobenzyl phthalate was higher than that of monobutyl phthalate in humans, although the reverse was observed in rats. Species difference in skin permeation profile corresponded to the esterase activity of the skin homogenate. Di(2-ethylhexyl) phthalate, which was not metabolized by esterases in the skin, was not transported across the skin. These results suggest that highly lipophilic phthalates may be transported easily across the stratum corneum lipids. The water-rich viable layer may become permeable to these phthalates by their metabolism into monoesters, which are relatively hydrophilic. Skin metabolism is essential to the percutaneous absorption of phthalates. Because esterase activity has large inter-individual differences, further study will be needed for individual risk identification of dermal exposure to phthalates. |
| キーワード | |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © 2017 Elsevier Inc. |
| このアイテムを表示する：本文(pdf) |  ( 371.5KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
