城西大学機関リポジトリJURATime of administration of acute or chronic doses of imipramine affects its antidepressant action in rats

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Time of administration of acute or chronic doses of imipramine affects its antidepressant action in rats

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ID	JOS-jcr.156
著者：名前	河合, 洋/Kodaira, Natsumi/Tanaka, Chika/石橋, 拓也/工藤, なをみ/川嶋, 洋一/光本, 篤史
著者：別形式	Kawai, Hiroshi / Kodaira, Natsumi / Tanaka, Chika / Ishibashi, Takuya / Kudo, Naomi / Kawashima, Yoichi / Mitsumoto, Atsushi
著者：カナ	カワイ, ヒロシ/コダイラ, ナツミ/タナカ, チカ/イシバシ, タクヤ/クドウ, ナオミ/カワシマ, ヨウイチ/ミツモト, アツシ
著者：所属	城西大学薬学部 / 城西国際大学薬学部 / 城西国際大学薬学部 / 城西国際大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西国際大学薬学部
著者：所属(別形式）	Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai International University, Faculty of Pharmaceutical Sciences / Josai International University, Faculty of Pharmaceutical Sciences / Josai International University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai International University, Faculty of Pharmaceutical Sciences
著者版フラグ	publisher
出版者	Ubiquity Press
電子ISSN	17403391
掲載誌名	Journal of Circadian Rhythms
巻	16
号	1
刊行年月	2018-05-10
開始ページ	1
終了ページ	9
コンテンツ作成日	2018-01-20
コンテンツ修正日	2018-03-24
コンテンツ登録日	2019-02-12
識別番号：DOI	info:doi/10.5334/jcr.156
識別番号：DOI（リンク）	https://doi.org/10.5334/jcr.156
抄録	The pathogenesis and therapeutics of depression are linked to the operation of the circadian system. Here, we studied the chronopharmacological action of a tricyclic antidepressant, imipramine. Male adult Wistar–Hannover rats were administered imipramine acutely or chronically in the morning or in the evening. The antidepressant action of imipramine was analyzed using the forced swim test (FST). A single dose of imipramine (30 mg/kg) in the morning, but not in the evening, reduced immobility and increased climbing in the FST. The plasma concentrations of imipramine and its metabolite, desipramine, were slightly higher in the morning than in the evening, which might explain the dosing time-dependent action of imipramine. Next, we analyzed the effect of chronic imipramine treatment. Rats received imipramine in the morning or in the evening for 2 weeks. The morning treatment resulted in larger effects in the FST than the evening treatment, and was effective at a dose that was ineffective when administered acutely. The levels of brain α-adrenergic receptors tended to decrease after chronic imipramine treatment. Imipramine might interact with noradrenergic neurons, and this interaction might chronically alter receptor expression. This alteration seemed greater in the morning than in the evening, which might explain the dosing time-dependent action of imipramine.
キーワード	Chronopharmacology/Imipramine/Forced swim test/Noradrenaline/α-Adrenergic receptor
注記	Article 5
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © 2018 The Author(s).
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