ID | JOS-jhs.57.341 |
著者:名前 | 柴, 祥子/ 角田, 伸代/ 伊藤, 可奈子/ 和久津, 昌紀/ 村木, 悦子/ 園田, 麻里子/ Tam, Phyllis S. Y./ 藤原, 葉子/ 池本, 真二/ 加園, 恵三 |
著者:別形式 | Shiba, Sachiko / Tsunoda, Nobuyo / Ito, Kanako / Wakutsu, Masaki / Muraki, Etsuko / Sonoda, Mariko / Tam, Phyllis S. Y. / Fujiwara, Yoko / Ikemoto, Shinji / Kasono, Keizo |
著者:カナ | シバ, サチコ/ ツノダ, ノブヨ/ イトウ, カナコ/ ワクツ, マサキ/ ムラキ, エツコ/ ソノダ, マリコ/ Tam, Phyllis S. Y./ フジワラ, ヨウコ/ イケモト, シンジ/ カソノ, ケイゾウ |
著者:所属 | 城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 / お茶の水女子大学 / お茶の水女子大学 / お茶の水女子大学 / お茶の水女子大学 / 城西大学薬学部医療栄養学科 |
著者:所属(別形式) | Josai University, Faculty of Pharmaceutical Science, Department of Clinical Dietetics and Human Nutrition / Josai University, Faculty of Pharmaceutical Science, Department of Clinical Dietetics and Human Nutrition / Josai University, Faculty of Pharmaceutical Science, Department of Clinical Dietetics and Human Nutrition / Josai University, Faculty of Pharmaceutical Science, Department of Clinical Dietetics and Human Nutrition / Josai University, Faculty of Pharmaceutical Science, Department of Clinical Dietetics and Human Nutrition / Ochanomizu University, Faculty of Human Life and Environmental Sciences, Department of Nutrition and Food Science / Ochanomizu University, Faculty of Human Life and Environmental Sciences, Department of Nutrition and Food Science / Ochanomizu University, Faculty of Human Life and Environmental Sciences, Department of Nutrition and Food Science / Ochanomizu University, Faculty of Human Life and Environmental Sciences, Department of Nutrition and Food Science / Josai University, Faculty of Pharmaceutical Science, Department of Clinical Dietetics and Human Nutrition |
著者版フラグ | publisher |
出版地 | 東京 |
出版者 | 日本薬学会 |
出版者:カナ | ニホンヤクガクカイ |
出版者:別名 | The Pharmaceutical Society of Japan |
NCID | AA11316464 |
冊子ISSN | 13449702 |
電子ISSN | 13475207 |
掲載誌名 | |
巻 | 57 |
号 | 4 |
刊行年月 | 2011 |
開始ページ | 341 |
終了ページ | 349 |
コンテンツ作成日 | 2011-02-21 |
コンテンツ修正日 | 2011-05-09 |
コンテンツ登録日 | 2013-07-16 |
識別番号:DOI | info:doi/10.1248/jhs.57.341 |
識別番号:DOI(リンク) | |
識別番号:その他 | JOI:JST.JSTAGE/jhs/57.341 |
抄録 | The components bringing the effects of fish oil on glucose and lipid metabolism are unclear. We used hydrogenated fish oil, which has saturated fatty acids with the same carbon chain lengths as the unsaturated fatty acids in fish oil, to clarify the functions of these unsaturated fatty acids on the improvements in lipid and glucose metabolism in mice. Mice divided into 3 groups were fed different diets: fish oil diet (FO), hydrogenated fish oil diet (HFO), and soybean oil diet (SBO) as a control. Body weight gain and white adipose tissue weight in the HFO and FO groups were significantly decreased compared with those in the SBO group. However, in the HFO group, the triglyceride (TG) levels in plasma were significantly decreased, while the lipids levels in the liver were remarkably increased compared with those in the FO group. Regarding the fatty acid composition in the liver and white adipose tissue in the HFO group, in parallel with the up-regulation of stearoyl-CoA desaturase 1 mRNA, relative amounts of C16:1 and C18:1 were significantly increased. By contrast, blood glucose levels in the oral glucose tolerance test had not deteriorated in the HFO group. Our results indicate that unsaturated fatty acids in the FO diet decrease lipid levels in the liver and maintain the balance of lipid levels in plasma, liver and white adipose tissue; in addition, in the HFO group, C16:1 and C18:1 synthesized in the liver and white adipose tissue may improve glucose tolerance and lipid metabolism. |
キーワード | |
言語 | eng |
資源タイプ | text |
ジャンル | |
フォーマット | application/pdf |
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