| ID | JOS-jjphcs.41.861 |
| タイトル：カナ | ガバペンチン ザザイ ノ インナイ セイザイカ ニ ムケタ ヤクブツ ドウタイガクテキ パラメータ ニ ヨル トクチョウヅケ |
| 別タイトル | Characterization of Pharmacokinetic Parameters for Hospital Preparation of a Suppository Containing Gabapentin Tablet |
| 著者：名前 | |
| 著者：別形式 | Arai, Narutoshi / Murata, Isamu / Ashiguchi, Arina / Nishiyama, Taisei / Inoue, Yutaka / Kimura, Masayuki / Kanamoto, Ikuo |
| 著者：カナ | |
| 著者：所属 | 小川赤十字病院薬剤部 / 城西大学薬学部医薬品安全性学講座 / 城西大学薬学部医薬品安全性学講座 / 城西大学薬学部医薬品安全性学講座 / 城西大学薬学部医薬品安全性学講座 / 城西大学薬学部医薬品安全性学講座 / 城西大学薬学部医薬品安全性学講座 |
| 著者：所属(別形式） | Japanese Red Cross Ogawa Hospital, Department of Pharmacy / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management |
| 著者版フラグ | publisher |
| 出版地 | 東京 |
| 出版者 | 日本医療薬学会 |
| 出版者：カナ | ニホンイリョウヤクガクカイ |
| 出版者：別名 | Japanese Society of Pharmaceutical health Care and Sciences |
| NCID | AA11527197 |
| 冊子ISSN | 1346342X |
| 電子ISSN | 18821499 |
| 掲載誌名 | |
| 掲載誌名：翻訳 | Japanese Journal of Pharmaceutical Health Care and Sciences |
| 巻 | 41 |
| 号 | 12 |
| 刊行年月 | 2015 |
| 開始ページ | 861 |
| 終了ページ | 869 |
| コンテンツ作成日 | 2015-07-16 |
| コンテンツ修正日 | 2015-10-09 |
| コンテンツ登録日 | 2017-02-06 |
| 識別番号：DOI | info:doi/10.5649/jjphcs.41.861 |
| 識別番号：DOI（リンク） | |
| 抄録 | Cancer pain often causes a decreased quality of life in patients. Gabapentin (GBP) is recommended as a supplementary analgesic for cancer-related pain, and can be taken at all steps of the World Health Organization pain relief ladder. However, GBP treatment is limited to oral administration. Therefore, a new route of administration is required for cancer patients who are unable to take oral medications.
In this study, we demonstrate the preparation method and characterize the pharmacokinetics of a suppository containing GBP in tablet form. The suppository bases polyethylene glycol (P), Witepsol H-15 (H), and Witepsol S-55 (S) were compared to find the optimal base for the suppositories. We compared intravenous (iv), per os (po), and intrarectal (ir) administration of GBP powder and tablet formulations: (GBPp and GBPt) prepared in a base of P, H, or S (GBPp/P, GBPp/H, GBPp/S, GBPt/P, GBPt/H, and GBPt/S). The hardness of the GBPt group was significantly lower than that of the GBPp group. The drug-release profiles of the GBPt suppository groups were highest, in the order H, P, and S. The drug-release profile of the GBPt/S group was significantly higher than that of the GBPp/S group. The time to maximum drug concentration of the GBPt/S group was significantly increased compared with the po, GBPt/P, and GBPt/H groups. The GBPt/H group had similar pharmacokinetic parameters to the po group. These results suggest that a suppository containing GBP tablet is better than the conventional preparation method for hospital preparation. |
| キーワード | |
| 言語 | jpn |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright ｃ 2015 日本医療薬学会 |
| このアイテムを表示する：本文(pdf) |  ( 680.5KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
