| ID | JOS-jjphcs.43.691 |
| タイトル：カナ | マオウトウ エキス オ ガンユウ シタ ケイコウ オヨビ チョクチョウナイ トウヨ ガ カノウ ナ チョコレート インナイ セイザイ ノ カイハツ ： ヒト カンノウ シケン オ モチイタ チョウセイ ホウホウ ノ ケッテイ ト ソノ セイザイテキ トクチョウ |
| 別タイトル | Study of Maoto Extract-containing Chocolate Formulations for Use in Hospitals:Chocolate Conditioning Method Using Human Sensory Tests and Characterization of the Maoto Extract-containing Formulations |
| 著者：名前 | |
| 著者：別形式 | Murata, Isamu / Abe, Keika / Saito, Miho / Inoue, Yutaka / Kanamoto, Ikuo |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部薬学科医薬品安全性学研究室 / 城西大学薬学部薬学科医薬品安全性学研究室 / 城西大学薬学部薬学科医薬品安全性学研究室 / 城西大学薬学部薬学科医薬品安全性学研究室 / 城西大学薬学部薬学科医薬品安全性学研究室 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Drug Safety Management |
| 著者版フラグ | publisher |
| 出版地 | 東京 |
| 出版者 | 日本医療薬学会 |
| 出版者：カナ | ニホンイリョウヤクガッカイ |
| 出版者：別名 | Japanese Society of Pharmaceutical Health Care and Sciences |
| 冊子ISSN | 1346342X |
| 電子ISSN | 18821499 |
| 掲載誌名 | |
| 掲載誌名：翻訳 | Japanese Journal of Pharmaceutical Health Care and Sciences |
| 巻 | 43 |
| 号 | 12 |
| 刊行年月 | 2017-12 |
| 開始ページ | 691 |
| 終了ページ | 700 |
| コンテンツ作成日 | 2017-08-15 |
| コンテンツ修正日 | 2017-11-02 |
| コンテンツ登録日 | 2019-01-31 |
| 識別番号：DOI | info:doi/10.5649/jjphcs.43.691 |
| 識別番号：DOI（リンク） | |
| NII論文ID | 130007528581 |
| 医中誌ID | 2018078997 |
| 抄録 | The influenza virus causes seasonal influenza epidemics and, from time to time, worldwide pandemics. Seasonal influenza epidemics in winter cause increased morbidity because vaccination is aimed at preventing influenza. However, influenza treatment is limited because oseltamivir cannot be used in children. Recently, Kampo medicine containing maoto was reported to have anti-viral and antipyretic effects. In Japan, maoto is generally administered as concentrated extract-granules. However, children do not like to take the maoto extract-granules because of their distinctive smell and bitter taste. Therefore, masking the smell and bitter taste is necessary for administration to children who are unable to take oral medications. In this study, we developed and characterized a new chocolate formulation for masking the maoto extract, using human sensory tests.The chocolate bases A to J (10 forms) were selected from commercial products. The total evaluation score for the maoto extract-containing chocolate formulation-D (Mao/nC) was the highest of the 10 forms according to the human sensory test results. The maoto extract-containing adjusted chocolate formulation (Mao/OrC) was based on an adjusted version of the Mao/nC formulation. The Mao/OrC exhibited improved smell and sweetness and overall evaluation scores compared with the Mao/nC, according to the human sensory test results. The results of a dissolution test, drug release test, and viscosity and osmotic pressure of the Mao/OrC were improved compared with those of the Mao/nC, and those of bioequivalence were similar. These results suggest that the Mao/OrC could be used as a new masking chocolate formulation for preparation in hospitals. |
| キーワード | |
| 言語 | jpn |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © 2017 日本医療薬学会 |
| このアイテムを表示する：本文(pdf) |  ( 1.8MB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
