城西大学機関リポジトリJURAPreparation and Evaluation of Liquid-Crystal Formulations with Skin-permeation-enhancing Abilities for Entrapped Drugs

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Preparation and Evaluation of Liquid-Crystal Formulations with Skin-permeation-enhancing Abilities for Entrapped Drugs

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ID	JOS-jos.60.31
著者：名前	山田, 圭祐/Yamashita, Jun/藤堂, 浩明/Miyamoto, Keiko/Hashimoto, Satoru/徳留, 嘉寛/橋本, フミ惠/杉林, 堅次
著者：別形式	Yamada, Keisuke / Yamashita, Jun / Todo, Hiroaki / Miyamoto, Keiko / Hashimoto, Satoru / Tokudome, Yoshihiro / Hashimoto, Fumie / Sugibayashi, Kenji
著者：カナ	ヤマダ, ケイスケ/ヤマシタ, ジュン/トウドウ, ヒロアキ/ミヤモト, ケイコ/ハシモト, サトル/トクドメ, ヨシヒロ/ハシモト, フミエ/スギバヤシ, ケンジ
著者：所属	城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 株式会社コスモステクニカルセンター / 株式会社コスモステクニカルセンター / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部
著者：所属(別形式）	Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Cosmos Technical Center Co., Ltd / Cosmos Technical Center Co., Ltd / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences
著者版フラグ	publisher
出版地	東京
出版者	日本油化学会
出版者：カナ	ニホンユカガクカイ
出版者：別名	Japan Oil Chemists' Society
NCID	AA11503337
冊子ISSN	13458957
電子ISSN	13473352
掲載誌名	Journal of Oleo Science
巻	60
号	1
刊行年月	2011
開始ページ	31
終了ページ	41
コンテンツ作成日	2010-05-16
コンテンツ修正日	2010-07-28
コンテンツ登録日	2017-12-25
識別番号：DOI	info:doi/10.5650/jos.60.31
識別番号：DOI（リンク）	http://doi.org/10.5650/jos.60.31
NII論文ID	130000438324
抄録	The usefulness of liquid crystals (LC) in topical formulations for application to skin was evaluated by measuring the in vitro permeation profile of a model compound, calcein, entrapped in a LC formulation, through excised hairless rat skin and a three-dimensional cultured human-skin model; the viability was determined using the MTT assay. Two physically stable LCs were prepared from a mixture of mono-, di-, and tri-esters 1, and monoesters 2, composed of erythritol and phytanylacetic acid. Cryo-transmission electron microscopy (cryo-TEM), electron diffraction patterns, and small-angle X-ray diffraction (SAXS) observations of the LC nanodispersions showed that the structures of the LCs were reverse hexagonal (LC-A) and cubic (LC-B). The skin-permeation properties of calcein were enhanced by entrapping in the LCs as a result of the increase in calcein partition from the LC dispersion solution into the skin; the properties were analyzed using a skin-permeation–time profile. Drug partitioning could also be modified by the LC structure. No skin damage was caused by the LC formulation in these experiments.The present study suggests that LC dispersions are potential additives in topical drug formulations and cosmetic formulations.
キーワード	liquid crystal/topical formulation/skin permeation/penetration enhancement
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © 2011 by Japan Oil Chemists' Society
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このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-jos.60.31

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