| ID | JOS-jphs.13149FP |
| 著者：名前 | |
| 著者：別形式 | Karahashi, Minako / Hoshina, Miki / Yamazaki, Tohru / Sakamoto, Takeshi / Mitsumoto, Atsushi / Kawashima, Yoichi / Kudo, Naomi |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西国際大学薬学部 / 城西大学薬学部 / 城西大学薬学部 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai International University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences |
| 著者版フラグ | author |
| 出版地 | 東京 |
| 出版者 | 日本薬理学会 |
| 出版者：カナ | ニホンヤクリガッカイ |
| 出版者：別名 | The Japanese Pharmacological Society |
| NCID | AA11806667 |
| 冊子ISSN | 13478648 |
| 電子ISSN | 13478613 |
| 掲載誌名 | |
| 巻 | 123 |
| 号 | 4 |
| 刊行年月 | 2013 |
| 開始ページ | 356 |
| 終了ページ | 370 |
| コンテンツ作成日 | 2013-08-19 |
| コンテンツ修正日 | 2013-10-09 |
| コンテンツ登録日 | 2015-02-26 |
| 識別番号：DOI | info:doi/10.1254/jphs.13149FP |
| 識別番号：DOI（リンク） | |
| 抄録 | Hepatic triacylglycerol (TAG) homeostasis is maintained by carefully regulated balance between its synthesis and disposal. Impairment in this balance causes steatosis. The aims of this study were i) to uncover whether fibrates control TAG concentration through the action of adipose triglyceride lipase (ATGL) and ii) to compare the potency of the effects on ATGL expression and TAG concentration among fenofibrate, bezafibrate, and clofibric acid in the liver of rats. Treatments of rats with the three fibrates induced ATGL and concomitantly decreased hepatic TAG concentration. The upregulation of ATGL was likely mediated through the activation of peroxisome proliferator-activated receptor α. Fibrates also expanded capacity of fatty acid β-oxidation. Importantly, three fibric acids (fenofibric, bezafibric, and clofibric acids) that are active metabolites formed in the liver exhibited almost the same potency to elevate ATGL expression in vivo, despite the fact that there were considerable differences in this regard among fenofibrate, bezafibrate, and clofibric acid when compared on the basis of their dosage. These results suggest that ATGL represents a potential therapeutic target for ameliorating hepatic steatosis and that fibric acids are promising agents to ameliorate and/or protect against hepatic steatosis. |
| キーワード | |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright ｃ2013 The Japanese Pharmacological Society |
| このアイテムを表示する：本文(pdf) |  ( 434.7KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
