| ID | JOS-jts.33.599 |
| 著者：名前 | |
| 著者：別形式 | Satoh, Yoko / Iwadate, Reiko / Watanabe, Yukino / Kawai, Hiroshi / Kudo, Naomi / Kawashima, Yoichi / Mitsumoto, Atsushi |
| 著者：カナ | |
| 著者：所属 | 城西国際大学薬学部 / 城西国際大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西国際大学薬学部 |
| 著者：所属(別形式） | Josai International University, Faculty of Pharmaceutical Sciences / Josai International University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai International University, Faculty of Pharmaceutical Sciences |
| 著者版フラグ | publisher |
| 出版地 | 東京 |
| 出版者 | 日本毒性学会 |
| 出版者：カナ | ニホンドクセイガッカイ |
| NCID | AN00002808 |
| 冊子ISSN | 03881350 |
| 電子ISSN | 18803989 |
| 掲載誌名 | |
| 巻 | 33 |
| 号 | 5 |
| 刊行年月 | 2008-12 |
| 開始ページ | 599 |
| 終了ページ | 608 |
| コンテンツ作成日 | 2008-09-18 |
| コンテンツ修正日 | 2008-10-10 |
| コンテンツ登録日 | 2016-12-26 |
| 識別番号：DOI | info:doi/10.2131/jts.33.599 |
| 識別番号：DOI（リンク） | |
| 抄録 | Most patients with hepatic porphyria exhibit neuropsychiatric symptoms, including abdominal pain, peripheral neuropathy, confusion, insomnia and mental disturbances such as anxiety and depression. Although heme deficiency and accumulation of heme precursors are thought to be responsible for neuropsychiatric manifestations in patients with acute porphyria, the pathogenetic mechanisms remain poorly understood. In the present study, we observed psychiatric behaviors in mice with hepatic porphyria induced by the ingestion of a griseofulvin (GF)-containing diet over a period of 12 weeks. GF ingestion by the mice caused an accumulation of porphyrins in the feces and a decrease in heme in the liver; these effects were observed throughout the entire duration of the experiment, with maximum levels observed after circa 1 week of ingestion of this diet. In addition, the mice developed enlargement of the liver, hepatocyte injury, and cholestasis. Mice with hepatic porphyria manifested an anxiety-like behavior by the long-term treatment (over 5 weeks) in a GF-dose and duration dependent manner. The hepatic porphyria mice also manifested depression-like behaviors by the short-term treatment (3 weeks) of GF2.0, which was reversed by administration of anti-depressant, imipramine. In conclusion, this study for the first time demonstrated psychiatric manifestations in GF-induced hepatic porphyria mice. The present results suggest that model animals could be useful for elucidating the mechanisms underlying psychiatric manifestations in syndromes such as hepatic porphyria and hepatic encephalopathy that are associated with the impairment of hepatic function. |
| キーワード | |
| 注記 | 「J-STAGE」で公開。 |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright c2009 The Japanese Society of Toxicology |
| このアイテムを表示する：本文(pdf) |  ( 551.9KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
