| ID | JOS-jts.39.475 |
| 著者：名前 | |
| 著者：別形式 | Sugino, Masahiro / Todo, Hiroaki / Suzuki, Takamasa / Nakada, Keiichi / Tsuji, Kiyomi / Tokunaga, Hiroshi / Jinno, Hideto / Sugibayashi, Kenji |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 神奈川県衛生研究所 / 国立医薬品食品衛生研究所生活衛生化学部 / 国立医薬品食品衛生研究所生活衛生化学部 / 城西大学薬学部 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Kanagawa Prefectural Institute of Public Health / National Institute of Health Sciences, Division of Environmental Chemistry / National Institute of Health Sciences, Division of Environmental Chemistry / Josai University, Faculty of Pharmaceutical Sciences |
| 著者版フラグ | publisher |
| 出版地 | 東京 |
| 出版者 | 日本毒性学会 |
| 出版者：カナ | ニホンドクセイガッカイ |
| NCID | AN00002808 |
| 冊子ISSN | 03881350 |
| 電子ISSN | 18803989 |
| 掲載誌名 | |
| 巻 | 39 |
| 号 | 3 |
| 刊行年月 | 2014 |
| 開始ページ | 475 |
| 終了ページ | 485 |
| コンテンツ作成日 | 2014-01-08 |
| コンテンツ修正日 | 2014-04-24 |
| コンテンツ登録日 | 2015-02-06 |
| 識別番号：DOI | info:doi/10.2131/jts.39.475 |
| 識別番号：DOI（リンク） | |
| 抄録 | Advances in the synthesis and utilization of new chemical compounds have led to improvements in our daily lives. However, new chemicals may be both beneficial and toxic. Thus, exposure to these new compounds should be restricted in an attempt to limit their potential toxicities. We predicted the safety of three biocides (p-cresol, diazinon and resmethrin) by comparing their skin permeability coefficients and desquamation rate (the counter flux of permeability coefficient for chemical compounds induced by skin turnover) following skin exposure. In vitro skin permeation experiments revealed that the permeability coefficients of diazinon and resmethrin were smaller than the desquamation rate; therefore, these biocides could not permeate the skin, which resulted in very low skin concentrations of these compounds. On the other hand, the skin concentration of p-cresol was high because of its higher permeability coefficient than the desquamation rate. Furthermore, low in vitro cell viability was reported for skin exposed to p-cresol. These results in the present study indicate that the method described herein is useful for predicting the toxicities of chemicals following their topical exposure. |
| キーワード | |
| 注記 | 「J-STAGE」で公開 |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright c2014 The Japanese Society of Toxicology |
| このアイテムを表示する：本文(pdf) |  ( 1.4MB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
