ID | JOS-koshohin.39.1 |
著者:名前 | |
著者:別形式 | Kitazawa, Kazuyuki / Kano, Satoshi / Hashimoto, Fumie / Sugibayashi, Kenji / Tokudome, Yoshihiro |
著者:カナ | |
著者:所属 | 城西大学薬学部 / マルホ株式会社京都R&Dセンター医薬品開発研究所 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 |
著者:所属(別形式) | Josai University, Faculty of Pharmaceutical Sciences / Maruho Co., Ltd., Kyoto R & D Center Drug Development Laboratories / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences |
著者版フラグ | publisher |
出版地 | 東京 |
出版者 | 日本香粧品学会 |
出版者:カナ | ニホンコウショウヒンガッカイ |
NCID | AA12025525 |
冊子ISSN | 18802532 |
電子ISSN | 21880719 |
掲載誌名 | |
掲載誌名:翻訳 | Journal of Japanese Cosmetic Science Society |
巻 | 39 |
号 | 1 |
刊行年月 | 2015 |
開始ページ | 1 |
終了ページ | 6 |
コンテンツ修正日 | 2015-01-22 |
コンテンツ登録日 | 2018-03-12 |
識別番号:DOI | info:doi/10.11469/koshohin.39.1 |
識別番号:DOI(リンク) | |
医中誌ID | 2015314975 |
抄録 | The physiological effects of chondroitin sulfate (CS) depend on the extent of its sulfation. This study focused on the effects of highly sulfated CS with different molecular weights in normal human dermal fibroblasts (NHDFs). NHDFs were treated with each CS. The expression of various genes was assessed by real-time PCR. Type I collagen content and elastin protein expression levels were assessed by ELISA and Western blotting, respectively. Disaccharide CS significantly increased the expression of genes required for extracellular matrix (collagen, type I, alpha I, decorin, elastin, lysyl oxidase, SMAD2 and SMAD3). In addition, we confirmed that collagen and elastin increased at the protein level. In contrast, highand low-molecular-weight CS polymer had no significant effect. Therefore, highly sulfated disaccharide CS increased the expression of extracellular matrix-related genes and proteins. It may be possible that the highly sulfated disaccharide CS may increase firmness and elasticity of skin. |
キーワード | |
注記 | 日本香粧品学会転載許諾済, 許諾番号JCSS R18-002 |
言語 | eng |
資源タイプ | text |
ジャンル | |
フォーマット | application/pdf |
権利 | Copyright © 2015 Japanese Cosmetic Science Society |
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