| ID | JOS-s10847-015-0504-0 |
| 著者:名前 | |
| 著者:別形式 | Seki, Tomohiro / Abe, Keigo / Nakamura, Kiminobu / Egawa, Yuya / Miki, Ryotaro / Juni, Kazuhiko / Seki, Toshinobu |
| 著者:カナ | |
| 著者:所属 | 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 |
| 著者:所属(別形式) | Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science |
| 著者版フラグ | author |
| 出版者 | Springer |
| NCID | AA12422343 |
| 冊子ISSN | 13883127 |
| 電子ISSN | 15731111 |
| 掲載誌名 | |
| 巻 | 82 |
| 号 | 3-4 |
| 刊行年月 | 2015-03-26 |
| 開始ページ | 417 |
| 終了ページ | 424 |
| コンテンツ作成日 | 2015-01-09 |
| コンテンツ修正日 | 2015-03-20 |
| コンテンツ登録日 | 2015-07-23 |
| 識別番号:DOI | info:doi/10.1007/s10847-015-0504-0 |
| 識別番号:DOI(リンク) | |
| 抄録 | We have designed a pseudopolyrotaxane (PPRX), known as a molecular necklace, consisting of phenylboronic acid-modified γ-cyclodextrin (PBA-γ-CyD) and naphthalene-modified polyethylene glycol (Naph-PEG) for developing sugar-responsive insulin delivery systems. Interestingly, structural analyses show that the Naph-PEG/PBA-γ-CyD PPRX obtained by our method was single stranded, whereas ordinary PPRXs using parent γ-CyD were double stranded. The Naph-PEG/PBA-γ-CyD PPRX was poorly water soluble at pH 7.4; however, sugar addition induced disintegration of the PPRX, and the components were dissolved, suggesting that the PBA moiety acts as a sugar sensor. We also have developed a PPRX consisting of Naph-PEG-appended insulin (Naph-PEG-Ins) and PBA-γ-CyD and have confirmed that the release rate of Naph-PEG-Ins was accelerated following sugar addition. |
| キーワード | |
| 注記 | This is a post-peer-review, pre-copyedit version of an article published in Journal of Inclusion Phenomena and Macrocyclic Chemistry. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10847-015-0504-0 |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| このアイテムを表示する:本文(pdf) |  ( 1.6MB) ダウンロード回数: 回 |
| このアイテムを表示する:URI | |