城西大学機関リポジトリJURAPolyol-responsive pseudopolyrotaxanes based on phenylboronic acid-modified polyethylene glycol and cyclodextrins

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Polyol-responsive pseudopolyrotaxanes based on phenylboronic acid-modified polyethylene glycol and cyclodextrins

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ID	JOS-s10847-017-0699-3
著者：名前	小島, 裕/岡野, 智之/関, 智宏/並木, 美仁/江川, 祐哉/三木, 涼太郎/從二, 和彦/関, 俊暢
著者：別形式	Kojima, Yu / Okano, Tomoyuki / Seki, Tomohiro / Namiki, Misato / Egawa, Yuya / Miki, Ryotaro / Juni, Kazuhiko / Seki, Toshinobu
著者：カナ	コジマ, ユウ/オカノ, トモユキ/セキ, トモヒロ/ナミキ, ミサト/エガワ, ユウヤ/ミキ, リョウタロウ/ジュウニ, カズヒコ/セキ, トシノブ
著者：所属	Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences
著者：所属(別形式）	城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部
著者版フラグ	author
出版地	Netherlands
出版者	Springer
冊子ISSN	13883127
電子ISSN	15731111
掲載誌名	Journal of Inclusion Phenomena and Macrocyclic Chemistry
巻	87
号	3-4
刊行年月	2017-04
開始ページ	295
終了ページ	303
コンテンツ作成日	2016-10-31
コンテンツ修正日	2017-02-02
コンテンツ登録日	2018-04-19
識別番号：DOI	info:doi/10.1007/s10847-017-0699-3
識別番号：DOI（リンク）	https://doi.org/10.1007/s10847-017-0699-3
抄録	Phenylboronic acid (PBA), which reacts with polyols to form cyclic esters, was attached to the amino terminal of polyethylene glycol (PEG) via amide bonds. PBA-PEG was used to prepare pseudopolyrotaxanes (pPRXs) by combining it with cyclodextrins (CyDs). In the case of α-CyD, a single stranded pPRX formed that disintegrated in the presence of catechol (CA), d-fructose (Fru), and d-glucose (Glc). The order of response was CA > Fru > Glc, which corresponds with the affinities between the PBA moiety and the polyols. In contrast, a pPRX using γ-CyD, which has a double-stranded structure, showed sugar-induced disintegration but did not show a response to CA. We explained these apparently curious responses of the pPRXs using a mechanism based on the penetrability of the polyol-bound PBA toward the cavities of the CyDs. The pPRXs, which are a class of molecular machine, show two selectivities; one is derived from polyol selectivity, and the other is based on the penetrability for CyDs.
キーワード	Pseudopolyrotaxane/Cyclodextrin/Boronic acid/Drug delivery/Stimuli-responsive material
注記	This is a post-peer-review, pre-copyedit version of an article published in Journal of Inclusion Phenomena and Macrocyclic Chemistry. The final authenticated version is available online at: http://dx.doi.org/10.1007//s10847-017-0699-3
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © Springer Science+Business Media Dordrecht 2017
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このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-s10847-017-0699-3

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