| ID | JOS-s11745-013-3839-6 |
| 著者：名前 | |
| 著者：別形式 | Tanaka, Shizuyo / Yamazaki, Tohru / Asano, Satoshi / Mitsumoto, Atsushi / Kobayashi, Daisuke / Kudo, Naomi / Kawashima, Yoichi |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部 / 城西大学薬学部 / 国際医療福祉大学 / 城西国際大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / International University of Health and Welfare, Department of Pharmaceutical Sciences / Josai International University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences |
| 著者版フラグ | author |
| 出版地 | Berlin |
| 出版者 | Springer |
| NCID | AA00275467 |
| 冊子ISSN | 00244201 |
| 電子ISSN | 15589307 |
| 掲載誌名 | |
| 巻 | 48 |
| 号 | 11 |
| 刊行年月 | 2013-11-01 |
| 開始ページ | 1115 |
| 終了ページ | 1134 |
| コンテンツ作成日 | 2013-08-24 |
| コンテンツ登録日 | 2014-03-26 |
| 識別番号：DOI | info:doi/10.1007/s11745-013-3839-6 |
| 識別番号：DOI（リンク） | |
| 抄録 | SHR/NDmcr-cp (cp/cp) rats (SHR/NDcp) are an animal model of metabolic syndrome. A previous study of ours revealed drastic increases in the mass of palmitic (16:0), oleic (18:1n-9), palmitoleic (16:1n-7), cis-vaccenic (18:1n-7) and 5,8,11-eicosatrienoic acids in the liver of SHR/NDcp. However, detailed information on the class of lipid accumulated and the mechanism responsible for the overproduction of the accumulated lipid in the liver was not obtained. This study aimed to characterize the class of lipid accumulated and to explore the mechanism underlying the lipid accumulation in the liver of SHR/NDcp, in comparison with SHR/NDmcr-cp (+/+) (lean hypertensive littermates of SHR/NDcp) and Wistar Kyoto rats. In the liver of SHR/NDcp, de novo synthesis of fatty acids (16:0, 18:1n-9 and 16:1n-7) and triacylglycerol (TAG) synthesis were up-regulated and fatty acid β-oxidation was down-regulated. These perturbations of lipid metabolism caused fat accumulation in hepatocytes and accumulation of TAG, which were enriched with 16:0, 18:1n-9 and 16:1n-7, in the liver of SHR/NDcp. On the other hand, no changes were found in hepatic contents of diacylglycerol and unesterified fatty acid (FFA); among FFA, there were no differences in the hepatic concentrations of unesterified 16:0 and stearic acid between SHR/NDcp and two other groups of rats. Moreover, little change was brought about in the expression of genes responsive to endoplasmic reticulum stress in the liver of SHR/NDcp. These results may reinforce the pathophysiological role of stearoyl-CoA desaturase 1 and fatty acid elongase 6 in the liver of SHR/NDcp. |
| キーワード | |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | c AOCS 2013 |
| このアイテムを表示する：本文(pdf) |  ( 1.3MB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
