城西大学機関リポジトリJURAInducing Effect of Clofibric Acid on Stearoyl-CoA Desaturase in Intestinal Mucosa of Rats

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Inducing Effect of Clofibric Acid on Stearoyl-CoA Desaturase in Intestinal Mucosa of Rats

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ID	JOS-s11745-014-3965-9
著者：名前	山崎, 研/門倉, 麻希子/武藤, 由季/坂本, 武史/岡﨑, 真理/光本, 篤史/川嶋, 洋一/工藤, なをみ
著者：別形式	Yamazaki, Tohru / Kadokura, Makiko / Mutoh, Yuki / Sakamoto, Takeshi / Okazaki, Mari / Mitsumoto, Atsushi / Kawashima, Yoichi / Kudo, Naomi
著者：カナ	ヤマザキ, トオル/カドクラ, マキコ/ムトウ, ユキ/サカモト, タケシ/オカザキ, マリ/ミツモト, アツシ/カワシマ, ヨウイチ/クドウ, ナオミ
著者：所属	城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西国際大学薬学部 / 城西大学薬学部 / 城西大学薬学部
著者：所属(別形式）	Josai University, School of Pharmaceutical Sciences / Josai University, School of Pharmaceutical Sciences / Josai University, School of Pharmaceutical Sciences / Josai University, School of Pharmaceutical Sciences / Josai University, School of Pharmaceutical Sciences / Josai International University, Faculty of Pharmaceutical Sciences / Josai University, School of Pharmaceutical Sciences / Josai University, School of Pharmaceutical Sciences
著者版フラグ	author
出版地	Berlin
出版者	Springer
NCID	AA00275467
冊子ISSN	00244201
電子ISSN	15589307
掲載誌名	Lipids
巻	49
号	12
刊行年月	2014-12
開始ページ	1203
終了ページ	1214
コンテンツ作成日	2014-08-21
コンテンツ修正日	2014-10-16
コンテンツ登録日	2015-02-19
識別番号：DOI	info:doi/10.1007/s11745-014-3965-9
識別番号：DOI（リンク）	http://dx.doi.org/10.1007/s11745-014-3965-9
抄録	Fibrates have been reported to elevate the hepatic proportion of oleic acid (18:1n-9) through inducing stearoyl-CoA desaturase (SCD). Despite abundant studies on the regulation of SCD in the liver, little is known about this issue in the small intestine. The present study aimed to investigate the effect of clofibric acid on the fatty acid profile, particularly monounsaturated fatty acids (MUFA), and the SCD expression in intestinal mucosa. Treatment of rats with a diet containing 0.5 % (w/w) clofibric acid for 7 days changed the MUFA profile of total lipids in intestinal mucosa; the proportion of 18:1n-9 was significantly increased, whereas those of palmitoleic (16:1n-7) and cis-vaccenic (18:1n-7) acids were not changed. Upon the treatment with clofibric acid, SCD was induced and the gene expression of SCD1, SCD2, and fatty acid elongase (Elovl) 6 was up-regulated, but that of Elovl5 was unaffected. Fat-free diet feeding for 28 days increased the proportions of 16:1n-7 and 18:1n-7, but did not effectively change that of 18:1n-9, in intestinal mucosa. Fat-free diet feeding up-regulated the gene expression of SCD1, but not that of SCD2, Elovl6, or Elovl5. These results indicate that intestinal mucosa significantly changes its MUFA profile in response to challenges by clofibric acid and a fat-free diet and suggest that up-regulation of the gene expression of SCD along with Elovl6 is indispensable to elevate the proportion of 18:1n-9 in intestinal mucosa.
キーワード	Stearoyl-CoA desaturase/Clofibric acid/Intestinal mucosa/Rat
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	c AOCS 2014
このアイテムを表示する：本文(pdf)	( 806.2KB) ダウンロード回数：回
このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-s11745-014-3965-9

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