| ID | JOS-yakushi.122.989 |
| タイトル：カナ | ヤクブツ ノ ジョホウセイ キノウ オ ユウスル コウクウナイ ソクホウ カイジョウ ノ ケンキュウ |
| 別タイトル | Fast-Disintegration Oral Tablets Having Sustained Release Property |
| 著者：名前 | |
| 著者：別形式 | Jin, Yi / Ohkuma, Hideki / Wang, Hua / Natsume, Hideshi / Sugibayashi, Kenji / Morimoto, Yasunori |
| 著者：カナ | |
| 著者：所属 | 浙江大学薬学院 / 城西大学薬学部 / 浙江大学薬学院 / 城西大学薬学部. TTS技術研究所 / 城西大学薬学部. TTS技術研究所 / 城西大学薬学部. TTS技術研究所 |
| 著者：所属(別形式） | Zhejiang University, College of Pharmacy / Josai University, Faculty of Pharmaceutical Sciences / Zhejiang University, College of Pharmacy / Josai University, Faculty of Pharmaceutical Sciences. Research Institute TTS Technology / Josai University, Faculty of Pharmaceutical Sciences. Research Institute TTS Technology / Josai University, Faculty of Pharmaceutical Sciences. Research Institute TTS Technology |
| 著者版フラグ | publisher |
| 出版地 | 東京 |
| 出版者 | 日本薬学会 |
| 出版者：カナ | ニホンヤクガクカイ |
| 出版者：別名 | The Pharmaceutical Society of Japan |
| NCID | AN00284903 |
| 冊子ISSN | 00316903 |
| 電子ISSN | 13475231 |
| 掲載誌名 | |
| 掲載誌名：翻訳 | 薬学雑誌 |
| 巻 | 122 |
| 号 | 11 |
| 刊行年月 | 2002-11 |
| 開始ページ | 989 |
| 終了ページ | 994 |
| コンテンツ作成日 | 2002-02-06 |
| コンテンツ修正日 | 2002-08-19 |
| コンテンツ登録日 | 2015-08-26 |
| 識別番号：DOI | info:doi/10.1248/yakushi.122.989 |
| 識別番号：DOI（リンク） | |
| 抄録 | Fast-disintegrating (FD) tablets containing nicorandil-loaded dry emulsions were prepared and their controlledrelease properties were examined and compared with the plain FD tablets (FD tablets without dry emulsions) and commercial tablets. The dry emulsions were prepared with myristyl alcohol and stearyl alcohol and their property was modified by mixing the ratio of the two alcohols. Disintegration time of the prepared FD tablets was sufficiently fast (i.e., 12 to 23 s). In vitro release of nicorandil from the FD tablets containing the dry emulsions was sustained over 6 h, while that from plain FD and commercial tablets was complate within 5 min. In vivo absorption of nicorandil from the tablets was evaluated by oral administration in beagle dogs. FD tablets containing dry emulsions showed a similar AUC, lower Cmax, and delayed Tmax compared to the plain FD and commercial tablets. These results suggest that the dry emulsionloaded FD tablets can be utilized to improve the sustained-release property of active drugs. |
| キーワード | |
| 言語 | jpn |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright c2002 The Pharmaceutical Society of Japan |
| このアイテムを表示する：本文(pdf) |  ( 559.8KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
