| ID | JOS-yakushi.129.253 |
| タイトル：カナ | コタイ ケイコウ ソクテイ ニヨル シクロデキストリン コンゴウ フンサイブツ チュウ ノp-ジメチルアミノベンゾニトリル ノ ブンシ ジョウタイ |
| 別タイトル | Solid states fluorescence study of p-dimethylaminobenzonitrile by co-grinding with cyclodextrins |
| 著者：名前 | |
| 著者：別形式 | Inoue, Yutaka / Ii, Noritaka / Yonemochi, Etsuo / Oguchi, Toshio / Higashi, Kenjirou / Moribe, Kunikazu / Yamamoto, Keiji |
| 著者：カナ | |
| 著者：所属 | 城西大学 薬学部医薬品安全性学講座 / 第一三共ヘルスケア株式会社研究開発部 / 東邦大学薬学部薬剤学教室 / 山梨大学医学部附属病院薬剤部 / 千葉大学大学院薬学研究院製剤工学研究室 / 千葉大学大学院薬学研究院製剤工学研究室 / 千葉大学大学院薬学研究院製剤工学研究室 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Daiichi Sankyo Healthcare Co., Ltd / Toho University, School of Pharmaceutical Sciences, Department of Pharmaceutics / University of Yamanashi, Department of Pharmacy / Chiba University, Graduate School of Pharmaceutical Sciences, Division of Pharmaceutical Technology / Chiba University, Graduate School of Pharmaceutical Sciences, Division of Pharmaceutical Technology / Chiba University, Graduate School of Pharmaceutical Sciences, Division of Pharmaceutical Technology |
| 著者版フラグ | publisher |
| 出版地 | 東京 |
| 出版者 | 日本薬学会 |
| 出版者：カナ | ニホンヤクガクカイ |
| 出版者：別名 | The Pharmaceutical Society of Japan |
| NCID | AN00284903 |
| 冊子ISSN | 00316903 |
| 電子ISSN | 13475231 |
| 掲載誌名 | |
| 掲載誌名：翻訳 | 薬学雑誌 |
| 巻 | 129 |
| 号 | 2 |
| 刊行年月 | 2009-02 |
| 開始ページ | 253 |
| 終了ページ | 262 |
| コンテンツ作成日 | 2008-10-27 |
| コンテンツ登録日 | 2013-10-28 |
| 識別番号：DOI | info:doi/10.1248/yakushi.129.253 |
| 識別番号：DOI（リンク） | |
| 識別番号：その他 | JOI:JST.JSTAGE/yakushi/129.253 |
| 抄録 | The molecular status of a freeze-dried sample or a ground mixture of p-dimethylaminobenzonitrile (DMABN) with α-, β-, or γ-cyclodextrins (CDs) was examined using solid-state fluorescence measurements. A twisted intramolecular charge transfer (TICT) emission of DMABN crystals was shown at 475 nm. Emission peaks of freeze-dried samples were observed at 450, 380, and 393 nm in α-CD/DMABN, β-CD/DMABN, and γ-CD/DMABN systems, respectively. It was speculated that DMABN molecules existed as a twisted form in the cavity of α-CD, and as a plane structure in that of β-CD or γ-CD. On the other hand, fluorescence emission peaks of ground mixtures of DMABN with α-, β-, or γ-CD were observed at around 450 nm. When DMABN was ground together with microcrystalline cellulose, which cannot form an inclusion complex, only TICT emission was detected. These results suggest that the observed shift in the fluorescence peak could be due to inclusion phenomena. When the ground mixtures were crystallized under humid conditions, fluorescence emission peaks were observed at 450 nm in α-CD and of around 400 nm in β- and γ-CD systems. It is concluded that the conformation of the DMABN molecules in a crystalline CD/DMABN inclusion complex change depending on the size of the CD cavity. |
| キーワード | |
| 言語 | jpn |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| このアイテムを表示する：本文(pdf) |  ( 810.3KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
