ID JOS-yakushi.131.745
著者:名前 著者:別形式 Oshima, Shigeru / Hatori, Yukiko / Honma, Seiichi / Terasawa, Katsutoshi / Saitoh, Yukiya / Kobayashi, Daisuke
著者:カナ 著者:所属 城西大学薬学部 / 城西大学薬学部 / 温故堂漢方あけぼの薬局 / 千葉大学大学院医学研究院 和漢診療学講座 / 城西大学薬学部 / 城西大学薬学部
著者:所属(別形式) Josai University, Faculty of Pharmaceutical Sciences, Department of Drug Informatics / Josai University, Faculty of Pharmaceutical Sciences, Department of Drug Informatics / Onko-Do Kampo Akebono Yakkyoku Co., Ltd / Chiba University, Graduate School of Medicine and School of Medicine, Department of Frontier Japanese Oriental “Kampo” Medicine, Department of Japanese Oriental “Kampo” Medicine / Josai University, Faculty of Pharmaceutical Sciences, Department of Drug Informatics /Josai University, Faculty of Pharmaceutical Sciences, Department of Drug Informatics /
著者版フラグ publisher
出版地 東京
出版者 日本薬学会
出版者:カナ ニホンヤクガクカイ
出版者:別名 The Pharmaceutical Society of Japan
NCID AN00284903
冊子ISSN 00316903
電子ISSN 13475231
掲載誌名 掲載誌名:翻訳 薬学雑誌
巻 131
号 5
刊行年月 2011-05
開始ページ 745
終了ページ 756
コンテンツ作成日 2011-02-08
コンテンツ登録日 2013-07-18
識別番号:DOI info:doi/10.1248/yakushi.131.745
識別番号:DOI(リンク) 識別番号:その他 JOI:JST.JSTAGE/yakushi/131.745
抄録 Reports have indicated a relationship between adverse drug reaction (ADR) and Human Leukocyte Antigen (HLA) polymorphism and a relationship between Body Constitution (BC) and HLA polymorphism. Thus, a relationship between ADR and BC is suggested. We therefore created a questionnaire (hereinafter “Questionnaire”) to survey the typical BC of Stevens-Johnson Syndrome (SJS) patients to determine how they differ from healthy persons, and studied the relationship between the development of SJS and BC. The Questionnaire had 30 typical items selected from those relevant to the BC necessary for the diagnosis and therapy of Sho-syndrome in Kampo Medicine. In the comparison of the prevalence of BCs between SJS patients and control persons, the prevalence of three BCs in the SJS group was significantly higher than that in the control group: 1) Does your throat ever feel closed up? Answer: Yes, 2) Do you easily feel hot flashes or burning cheeks even though your hands and feet feel cold? Answer: Yes, and 3) Do your lips or gums look dull red? Answer: Yes. In the analysis using the decision tree, the concentrated group of SJS patients (eightyfold) was extracted using two decision trees consisting of 3 index variables. Persons with BCs from any of 1) to 3) are suggested to be at high risk of developing SJS.
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