| ID | JOS-yakushi.132.763 |
| タイトル：カナ | ベイズ リロン ニ モトヅク ショキ ショウジョウ ノ ジョウホウ カチ ニ カンスル テイリョウテキ ヒョウカ シュホウ ノ ケントウ |
| 別タイトル | Quantitative Evaluation Method of Information Value of Initial Symptoms Based on Bayesian Theory |
| 著者：名前 | |
| 著者：別形式 | Ohshima, Shigeru / Ieda, Mayuko / Yamamoto, Midori / Kobayashi, Daisuke |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部薬剤作用解析学講座 / 本庄総合病院 / 城西大学薬学部薬剤作用解析学講座 / 城西大学薬学部薬剤作用解析学講座 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmaceutical Sciences, Department of Analytical Pharmaceutics and Informatics / Honjo General Hospital, Department of Pharmacy / Josai University, Faculty of Pharmaceutical Sciences, Department of Analytical Pharmaceutics and Informatics / Josai University, Faculty of Pharmaceutical Sciences, Department of Analytical Pharmaceutics and Informatics / |
| 著者版フラグ | publisher |
| 出版地 | 東京 |
| 出版者 | 日本薬学会 |
| 出版者：カナ | ニホンヤクガクカイ |
| 出版者：別名 | The Pharmaceutical Society of Japan |
| NCID | AN00284903 |
| 冊子ISSN | 00316903 |
| 電子ISSN | 13475231 |
| 掲載誌名 | |
| 掲載誌名：翻訳 | 薬学雑誌 |
| 巻 | 132 |
| 号 | 6 |
| 刊行年月 | 2012-06 |
| 開始ページ | 763 |
| 終了ページ | 768 |
| コンテンツ作成日 | 2012-03-15 |
| コンテンツ登録日 | 2013-07-18 |
| 識別番号：DOI | info:doi/10.1248/yakushi.132.763 |
| 識別番号：DOI（リンク） | |
| 識別番号：その他 | JOI:DN/JST.JSTAGE/yakushi/132.763 |
| 抄録 | In accordance with Article 25-2 of the Pharmacists Act, pharmacists provide patients with information about the initial symptoms of adverse drug reactions for detecting and preventing those reactions. Thus far, however, there have been no reports quantitatively evaluating the usefulness of such information. We present a theory of information evaluation using posterior probability (PP), positive likelihood ratio (LR(+)) and incidence of nonspecific initial symptoms (NIS)?a measure of general symptoms without anything come to mind. First, we calculated using the data from the clinical trials. For liver damage caused by loxoprofen sodium hydrate, the LR(+) was as high as 27.9 in the presence of rash, but the PP was 0.002067, which means there were only 2 liver damage cases among 1000 rash cases. Calculated in the same way for voriconazole, the LR(+) was 5 and the PP was 0.2 (1 liver damage case among 5 rash cases). This suggests that information about rash as an initial symptom of liver damage is useful for patients taking voriconazole. However, the PP was greatly reduced when it was calculated by considering NIS. Since patients cannot distinguish initial symptom of side effect from mere change in body condition, the calculation considering NIS is realistic. Therefore, it is necessary to study in order to raise the value of the information service of the pharmacist. Our study demonstrates how PP and NIS, our new effective measure, allow a quantitative evaluation of the usefulness of information about initial symptoms. |
| キーワード | |
| 言語 | jpn |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| このアイテムを表示する：本文(pdf) |  ( 333.9KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
