| ID | JOS-yakushi.14-00219 |
| タイトル：カナ | Crush syndrome モデル ラット ニオケル dexamethasone ノ ヤクブツ ドウタイ ノ ヘンカ ト トクチョウ |
| 別タイトル | Pharmacokinetics Characteristics of Dexamethasone in Crush Syndrome Model Rats |
| 著者：名前 | |
| 著者：別形式 | Murata, Isamu / Otsuka, Akio / Hara, Chihiro / Motohashi, Risa / Kouno, Shiho / Inoue, Yutaka / Kanamoto, Ikuo |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医薬品安全性学研究室 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management |
| 著者版フラグ | publisher |
| 出版地 | 東京 |
| 出版者 | 日本薬学会 |
| 出版者：カナ | ニホンヤクガクカイ |
| 出版者：別名 | The Pharmaceutical Society of Japan |
| NCID | AN00284903 |
| 冊子ISSN | 00316903 |
| 電子ISSN | 13475231 |
| 掲載誌名 | |
| 掲載誌名：翻訳 | 薬学雑誌 |
| 巻 | 135 |
| 号 | 2 |
| 刊行年月 | 2015-02 |
| 開始ページ | 315 |
| 終了ページ | 322 |
| コンテンツ作成日 | 2014-08-28 |
| コンテンツ修正日 | 2014-10-10 |
| コンテンツ登録日 | 2015-03-31 |
| 識別番号：DOI | info:doi/10.1248/yakushi.14-00219 |
| 識別番号：DOI（リンク） | |
| 抄録 | Crush syndrome (CS) is characterized by ischemia/reperfusion-induced rhabdomyolysis and subsequent systemic inflammation and has a high mortality rate, even when treated with conventional therapy. In previous studies, we demonstrated that treatment of rats with acute lethal CS using dexamethasone (DEX) had therapeutic effects in laboratory findings and improved the clinical course of CS. However, because the application of DEX in CS therapy is unknown, evaluation of the pharmacokinetic parameters of DEX was considered essential to support its clinical use. Here, we investigated the pharmacokinetic characteristics of DEX in a rat model of CS. Anesthetized rats were subjected to bilateral hind limb compression using rubber tourniquets for 5 h, followed by reperfusion for 0 to 24 h. Rats were divided randomly into 4 groups: saline-treated sham (S) and CS groups and 5.0 mg/kg DEX-treated S (S-DEX) and CS (CS-DEX) groups. Blood and tissue samples were collected for HPLC analysis. In the CS-DEX group, the pharmacokinetic parameters of the area under the concentration-time curve, mean residence time, and distribution volume levels increased significantly compared to the S-DEX group, whereas total body clearance, elimination rate constant, and renal clearance levels decreased significantly. Moreover, decrease of muscle tissue DEX concentration and of CYP3A activity were observed in the CS-DEX group. These results show the pharmacokinetic characteristics of DEX in the rat CS model and support the potential use of DEX in disaster medical care. |
| キーワード | |
| 言語 | jpn |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright c2015 The Pharmaceutical Society of Japan |
| このアイテムを表示する：本文(pdf) |  ( 398.1KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
