| ID | JOS-yakushi.18-00010 |
| タイトル：カナ | インナイ セイザイ ニ オケル リックンシトウ エキス ガンユウ ザザイ ノ セイザイガク テキ トクセイ オヨビ ラット オ モチイタ セイブツガク テキ ドウトウ セイ ノ ヒョウカ |
| 別タイトル | Pharmaceutical Properties of Rikkunshito Extract Suppository and Bioequivalence by Pharmacokinetic Parameters and EŠectiveness against Nausea and Vomiting and Anorexia in Rats |
| 著者：名前 | 村田, 勇/ 西山, 大青/ 川崎, 浩範/ 内藤, 千鶴/ 鎌田, 武志/ 古河, 義行/ 岩田, 萌子/ 杉野, 雅浩/ 井上, 裕/ 金本, 郁男 |
| 著者：別形式 | Murata, Isamu / Nishiyama, Taisei / Kawasaki, Hironori / Naito, Chizuru / Kamata, Takeshi / Furukawa, Yoshiyuki / Iwata, Moeko / Sugino, Masahiro / Inoue, Yutaka / Kanamoto, Ikuo |
| 著者：カナ | ムラタ, イサム/ ニシヤマ, タイセイ/ カワサキ, ヒロノリ/ ナイトウ, チズル/ カマタ, タケシ/ フルカワ, ヨシユキ/ イワタ, モエコ/ スギノ, マサヒロ/ イノウエ, ユタカ/ カナモト, イクオ |
| 著者：所属 | 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部薬剤学研究室 / 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医薬品安全性学研究室 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Pharmaceutics / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management |
| 著者版フラグ | publisher |
| 出版地 | 東京 |
| 出版者 | 日本薬学会 |
| 出版者：カナ | ニホンヤクガクカイ |
| 出版者：別名 | The Pharmaceutical Society of Japan |
| NCID | AN00284903 |
| 冊子ISSN | 00316903 |
| 電子ISSN | 13475231 |
| 掲載誌名 | |
| 掲載誌名：翻訳 | 薬学雑誌 |
| 巻 | 138 |
| 号 | 9 |
| 刊行年月 | 2018-09 |
| 開始ページ | 1169 |
| 終了ページ | 1179 |
| コンテンツ作成日 | 2018-02-02 |
| コンテンツ修正日 | 2018-05-06 |
| コンテンツ登録日 | 2019-02-12 |
| 識別番号：DOI | info:doi/10.1248/yakushi.18-00010 |
| 識別番号：DOI（リンク） | |
| 抄録 | In patients with cancer, it is difficult to continue medical treatment owing to nausea and vomiting (NV). Therefore, it is important to avoid these problems for improving the patient's QOL. Rikkunshito extract (RK) possesses antiemetic effects and is used in combination in cancer therapy. However, patients with cancer find it difficult to take the medicine orally for the treatment of NV and anorexia owing to the characteristic smell and taste of traditional Chinese medicine. We examined the pharmaceutical properties of RK suppository for hospital use, assessed bioequivalence by using pharmacokinetic parameters, and determined its effectiveness against NV and anorexia in rats. In this study, RK suppository was prepared by using RK formulation (A, B, and C) and Witepsol (H and S) (AH, BH, CH, AS, BS, and CS). Pharmaceutical properties, namely, hardness, dispersibility, long-term stability, and drug (hesperidin and glycyrrhizic acid) release were measured for AH, BH, AH, and AS. The pharmacokinetic parameters, effectiveness of substance P against NV and anorexia, and serotonin-activated ghrelin levels were assessed for BH only. AH, BH, AS, and AS demonstrated uniform and sufficient hardness. The release rate of oleaginous components, such as glycyrrhizic acid, did not change significantly, while that of water soluble components, such as hesperidin, decreased when compared with that in powder formulations A and B. NV and anorexia improved in rats administered BH compared with the control group. BH suppository showed effectiveness in terms of both physicochemical property and bioequivalence for hospital use. |
| キーワード | |
| 言語 | jpn |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © 2018 The Pharmaceutical Society of Japan |
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| このアイテムを表示する：URI | |
