| ID | JOS-0258851X-26-259 |
| 著者：名前 | 坂上, 宏/ 岩本, 祥子/ Matsuta, Tomohiko/ 佐藤, 和恵/ 島田, 智哉子/ 金本, 大成/ 寺久保, 繁美/ 中島, 秀喜/ Morita, Yurika/ 大久保, 温子/ 津田, 整/ 須永, 克佳/ Kitajima, Madoka/ Oizumi, Hiroshi/ Oizumi, Takaaki |
| 著者：別形式 | Sakagami, Hiroshi / Iwamoto, Shoko / Matsuta, Tomohiko / Satoh, Kazue / Shimada, Chiyako / Kanamto, Taisei / Terakubo, Shigemi / Nakashima, Hideki / Morita, Yurika / Ohkubo, Atsuko / Tsuda, Tadashi / Sunaga, Katsuyoshi / Kitajima, Madoka / Oizumi, Hiroshi / Oizumi, Takaaki |
| 著者：カナ | サカガミ, ヒロシ/ イワモト, ショウコ/ マツタ, トモヒコ/ サトウ, カズエ/ シマダ, チヤコ/ カナモト, タイセイ/ テラクボ, シゲミ/ ナカシマ, ヒデキ/ モリタ, ユリカ/ オオクボ, アツコ/ ツダ, タダシ/ スナガ, カツヨシ/ キタジマ, マドカ/ オオイズミ, ヒロシ/ オオイズミ, タカアキ |
| 著者：所属 | 明海大学歯学部 / 明海大学歯学部 / 明海大学歯学部 / 明海大学歯学部 / 明海大学歯学部 / 聖マリアンナ医科大学 / 聖マリアンナ医科大学 / 聖マリアンナ医科大学 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 大和生物研究所 / 大和生物研究所 / 大和生物研究所 |
| 著者：所属(別形式） | Meikai University School of Dentistry / Meikai University School of Dentistry / Meikai University School of Dentistry / Meikai University School of Dentistry / Meikai University School of Dentistry / St. Marianna University School of Medicine / St. Marianna University School of Medicine / St. Marianna University School of Medicine / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Daiwa Biological Research Institute Co., Ltd. / Daiwa Biological Research Institute Co., Ltd. / Daiwa Biological Research Institute Co., Ltd. |
| 著者版フラグ | publisher |
| 出版地 | Athens |
| 出版者 | International Institute of Anticancer Research |
| NCID | AA10714348 |
| 冊子ISSN | 0258851X |
| 掲載誌名 | |
| 巻 | 26 |
| 号 | 2 |
| 刊行年月 | 2012-03 |
| 開始ページ | 259 |
| 終了ページ | 264 |
| コンテンツ作成日 | 2011-12-22 |
| コンテンツ登録日 | 2013-04-15 |
| 抄録 | Background: We have previously reported that alkaline extract of Sasa senanensis leaves (SE) has several biological activities characteristic of lignin-carbohydrate complex (LCC). In the present study, we compared the biological activity of three commercially available products of SE (products A, B and C). Materials and Methods: Cell viability of mock-infected, HIV-infected, UV-irradiated cells was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide method. Radical intensity was determined by electron spin resonance spectroscopy. Cytochrome P-450 (CYP)3A4 activity was measured by β-hydroxylation of testosterone in human recombinant CYP3A4. Results: Product A is a pure SE that contains Fe(II)-chlorophyllin, whereas products B and C contain Cu(II)-chlorophyllin and less LCC. Product C is supplemented with ginseng and pine (Pinus densiflora) leaf extracts. Product A exhibited 5-fold higher anti-HIV, 4-fold higher anti-UV, 5-fold higher hydroxyl radical-scavenging, and 3-fold lower CYP3A4 inhibitory activities as compared to those of product B, and 5-fold higher, 1.5-fold higher, comparable, and 7-fold lower activities, respectively, as compared to those of product C. Conclusion: The present study demonstrates for the first time the superiority of product A over products B and C, suggesting the beneficial role of LCC and Fe(II)-chlorophyllin. |
| キーワード | |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| このアイテムを表示する：本文(pdf) |  ( 306.0KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
