| ID | JOS-03727629-58_164 |
| タイトル：カナ | シンキ インスリン カートリッジ セイザイ ノ ガンリョウ キンイツセイ ニ ツイテ ノ バリデーション |
| 別タイトル | Validation for Drug Content of New lnsulin Cartrid |
| 著者：名前 | |
| 著者：別形式 | Komada, Fusao / Ohmichi, Rumi / Hatanaka, Hisakatu / Tanigawara, Yusuke / Okumura, Katsuhiko |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部医薬品情報学教室 / 神戸大学医学部附属病院薬剤部 / 兵庫県立衛生研究所食品薬品部 / 神戸大学医学部附属病院薬剤部 / 神戸大学医学部附属病院薬剤部 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmaceutical Sciences / Kobe University, School of Medicine Department of Hospital Pharmacy / Hyogo Prefectural Institute of Public Health / Kobe University, School of Medicine Department of Hospital Pharmacy / Kobe University, School of Medicine Department of Hospital Pharmacy |
| 著者版フラグ | publisher |
| 出版地 | 東京 |
| 出版者 | 日本薬剤学会 |
| 出版者：カナ | ニホンヤクザイガッカイ |
| 出版者：別名 | The Academy of Pharmaceutical Science and Technology, Japan |
| NCID | AN00266708 |
| 冊子ISSN | 03727629 |
| 掲載誌名 | |
| 掲載誌名：翻訳 | Journal of Pharmaceutical Science and Technology, Japan |
| 巻 | 58 |
| 号 | 3 |
| 刊行年月 | 1998 |
| 開始ページ | 164 |
| 終了ページ | 169 |
| コンテンツ作成日 | 1998-07-06 |
| コンテンツ登録日 | 2012-03-14 |
| 抄録 | We studied the validation for drug content of a new insulin cartridge (Humacart 3/7, 3.0 ml cartridgeR). The concentrations of total insulin, Zn, m-cresol, and phenol in the Humacart 3/7, 3.0 ml cartridgeR were consistent with the levels described in the interview form. To study the relationship between the mixing (O, 5, and 10 times) and the uniformity of the insulin suspension, a Humacart 3/7, 3.0 ml cartridgeR was set into the insulin delivery device specifically designed for this cartridge (AutopenR). The total insulin concentrations of this preparation through AutopenR varied from 30 to 150 U/ml without mixing, so mixing more than 10 times was necessary to make the suspension uniform. The total insulin concentrations througih AutopenR decreased with increased standing times after thorough mixing; thus the Humacart 3/7, 3.0 ml cartridgeR must be injected as soon as possible after mixing. The dimeric-hexameric insulin concentration in the Humacart 3/7, 3.0 ml cartridgeR was 10 times higher than the monomeric insulin concentration. Furthermore, the insulin concentration through AutopenR with a 31-gauge needle was the same as the insulin concentration using a 30-gauge needle. These results indicate that the characteristics of a Humacart, 3/7, 3.0 ml cartridgeR are equivalent to that of a Humacart 3/7, l.5 ml cartridgeR. |
| キーワード | |
| 注記 | [ノート] |
| 言語 | jpn |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| このアイテムを表示する：本文(pdf) |  ( 942.9KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
