| ID | JOS-1475-2840-10-34 |
| 著者：名前 | |
| 著者：別形式 | Nakajima, Kei / Nemoto, Tohru / Muneyuki, Toshitake / Kakei, Masafumi / Fuchigami, Hiroshi / Munakata, Hiromi |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部 / 城西大学薬学部 / 自治医科大学医学部 / 自治医科大学医学部 / 社会保険大宮総合病院 / 社会保険大宮総合病院 |
| 著者：所属(別形式） | Ｊosai University, Faculty of Pharmaceutical Sciences, Department of Medical Dietetics, Division of Clinical Nutrition / Ｊosai University, Faculty of Pharmaceutical Sciences, Department of Medical Dietetics, Division of Clinical Nutrition / Jichi Medical University School of Medicine, Saitama Medical Center, First Department of Comprehensive Medicine / Jichi Medical University School of Medicine, Saitama Medical Center, First Department of Comprehensive Medicine / Social Insurance Omiya General Hospital, Department of Health Care Center / Social Insurance Omiya General Hospital, Department of Internal Medicine |
| 著者版フラグ | publisher |
| 出版者 | BioMed Central |
| NCID | AA12050431 |
| 電子ISSN | 14752840 |
| 掲載誌名 | |
| 巻 | 10 |
| 号 | 34 |
| 刊行年月 | 2011-04 |
| コンテンツ作成日 | 2011-04-17 |
| コンテンツ登録日 | 2011-07-16 |
| 識別番号：DOI | info:doi/10.1186/1475-2840-10-34 |
| 識別番号：DOI（リンク） | |
| PubMed番号 | info:pmid/21496338 |
| 抄録 | Background: Low serum amylase levels may reflect impaired exocrine-endocrine relationship in the pancreas.However, few clinical studies have addressed this issue. Therefore, in this epidemiological study, we investigatedwhether low serum amylase was associated with the pathogenesis of impaired insulin action: metabolic syndrome(MetS) and diabetes.Research Design and Methods: Serum amylase, cardiometabolic risk factors, MetS (Adult Treatment Panel IIIcriteria), and diabetes were examined in 2,425 asymptomatic subjects aged 30-80 years who underwent medicalcheckups recently (April 2009-March 2010) and 5 years ago.Results: Clinical variables, except for age and estimated glomerular filtration rate (eGFR), shifted favorably withincreasing serum amylase levels. Plasma glucose levels at 1- and 2-hr during OGTT increased significantly withdecreasing serum amylase levels. Multiple logistic analyses showed that, compared with highest quartile of serumamylase, lowest quartile was associated with increased risk for MetS and diabetes after adjustment for confoundingfactors [odds ratio (95% CI), 2.07 (1.39-3.07) and 2.76 (1.49-5.11), respectively]. In subjects who underwent checkups5 years ago (n = 571), lower amylase at the previous checkup were associated with larger numbers of metabolicabnormalities at the recent checkup. The fluctuation over time in serum amylase levels in subjects with low serumamylase at the previous checkup was slight and was unaffected by kidney dysfunction.Conclusions: Our results indicate that low serum amylase is associated with increased risk of metabolicabnormalities, MetS and diabetes. These results suggest a pancreatic exocrine-endocrine relationship in certainclinical conditions. |
| キーワード | |
| 注記 | Licensee BioMed Central Ltd. This is an Open Access Article. 8p. |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| このアイテムを表示する：本文(pdf) |  ( 392.5KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
