城西大学機関リポジトリJURAUrinary Bile Acid Shows Diurnal Fluctuation and Phase Shift with Daytime-Restricted Feeding in Rats

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Urinary Bile Acid Shows Diurnal Fluctuation and Phase Shift with Daytime-Restricted Feeding in Rats

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ID	JOS-2434432X-3-60
著者：名前	河合, 洋/黒川, 愛/石橋, 拓也/岩舘, 怜子/工藤, なをみ/川嶋, 洋一/光本, 篤史
著者：別形式	Kawai, Hiroshi / Kurokawa, Ai / Ishibashi, Takuya / Iwadate, Reiko / Kudo, Naomi / Kawashima, Yoichi / Mitsumoto, Atsushi
著者：カナ	カワイ, ヒロシ/クロカワ, アイ/イシバシ, タクヤ/イワダテ, レイコ/クドウ, ナオミ/カワシマ, ヨウイチ/ミツモト, アツシ
著者：所属	城西大学薬学部 / 城西国際大学薬学部 / 立命館大学グローバル・イノベーション研究機構 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西国際大学薬学部
著者：所属(別形式）	Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai International University, Faculty of Pharmaceutical Sciences / Ritsumeikan University, Global Innovation Research Organization / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai International University, Faculty of Pharmaceutical Sciences
著者版フラグ	publisher
出版地	東京
出版者	日本薬学会
出版者：カナ	ニホンヤクガクカイ
出版者：別名	The Pharmaceutical Society of Japan
電子ISSN	2434432X
掲載誌名	BPB Reports
巻	3
号	2
刊行年月	2020-03
開始ページ	60
終了ページ	64
コンテンツ作成日	2020-01-09
コンテンツ修正日	2020-03-02
コンテンツ登録日	2020-05-28
識別番号：DOI	info:doi/10.1248/bpbreports.3.2_60
識別番号：DOI（リンク）	https://doi.org/10.1248/bpbreports.3.2_60
抄録	Dysregulation of the biological clock disrupts the homeostasis of physiological functions, which may lead to the development of various disorders. To investigate the relationship between biological rhythms and disorders, an efficient monitoring method of the biological clock is necessary. In this study, we analyzed the circadian rhythmicity profile of bile acids in urine and investigated whether urinary bile acid (UBA) could reflect the circadian rhythm in liver physiology. Male Wistar-Hannover rats were maintained in metabolic cages under ad lib feeding and later subjected to restricted feeding (in which rats were fed only during light periods). Excreted urine was collected in each session, and bile acid contents were analyzed via an enzyme-based total bile acid assay. UBA content showed diurnal fluctuations under both ad lib and restricted feeding conditions and reached a peak during the dark period of ad lib feeding. In contrast, with restricted feeding, the peak was observed during light periods. Restricted feeding induced an 8-12 h phase shift. Diurnal fluctuation and phase shift by restricted feeding are distinctive features controlled by biological clocks in peripheral tissues. Since bile acids are synthesized in the liver, we propose that UBA might reflect the circadian fluctuation in liver physiology.
キーワード	circadian rhythm/概日リズム/bile acid/胆汁酸/liver/肝臓/urine/尿/restricted feeding/摂食制限
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © 2020 The Pharmaceutical Society of Japan
このアイテムを表示する：本文(pdf)	ダウンロード回数：回
このアイテムを表示する：URI	https://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-2434432X-3-60

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