| ID | JOS-2470-1009.160 |
| 著者：名前 | |
| 著者：別形式 | Yoshimura, Kana / Inoue, Yutaka / Koizumi, Akihiko / Suzuki, Mitsuaki / Itakura, Shoko / Todo, Hiroaki / Murata, Isamu / Kanamoto, Ikuo |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学理学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Science / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences |
| 著者版フラグ | publisher |
| 出版地 | CA |
| 出版者 | Sci Forschen |
| 電子ISSN | 24701009 |
| 掲載誌名 | |
| 巻 | 7 |
| 号 | 1 |
| 刊行年月 | 2021-05 |
| 開始ページ | 1 |
| 終了ページ | 7 |
| コンテンツ作成日 | 2021-04-27 |
| コンテンツ修正日 | 2021-05-14 |
| コンテンツ登録日 | 2021-09-21 |
| 識別番号：DOI | info:doi/10.16966/2470-1009.160 |
| 識別番号：DOI（リンク） | |
| 抄録 | Purpose: The aims of this study were to prepare a 0.1% Miconazole (MCZ) eye-drop solution and to evaluate the stability and physical properties of the preparation.Methods: For 0.1% MCZ eye-drops (containing 1mg/mL MCZ), a Normal Saline Solution (NSS)-added system in which MCZ injection was diluted with NSS, an L-lactate Ringer’s Solution (LRS)-added system diluted with LRS and NSS, and a lactic acid-added system diluted with lactic acid and NSS were aseptically prepared. The storage conditions for the NSS-added system were dark condition (25°C, RH84%), cold condition (4°C), and severe condition (40°C, RH82%). The LRS-added system and the lactic acid-added system were stored only at 4°C.Results: MCZ eye-drops diluted with physiological saline showed a reduction in MCZ content to approximately 90% after 2 weeks of storage at 4°C, and precipitates were confirmed in the eye-drop solution. The pH was maintained at 4.8 and the osmolality at 280mOsmol/kg. When lactic acid was added at concentrations of 1% and 0.5%, MCZ precipitation was confirmed after storage for 4 weeks, and the MCZ content decreased to ≤ 90%, with a pH of approximately 3.0-3.5. However, when 0.3% lactic acid was added, the MCZ content was maintained after 4 weeks, but the pH dropped to about 3.9.Conclusion: These results suggest that storing MCZ eye-drops at 4°C for 7 days is reasonable. In addition, the storage period could be extended up to 4 weeks under conditions of 25°C, RH84% or 40°C, RH82%. MCZ eye-drop solution containing 0.3% lactic acid can remain stable for 2 weeks when stored at 4°C. |
| キーワード | |
| 注記 | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © 2021 Yoshimura K, et al. |
| このアイテムを表示する：本文(pdf) |  ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
