城西大学機関リポジトリJURAImprovement of the Solubility and Evaluation of the Physical Properties of an Inclusion Complex Formed by a New Ferulic Acid Derivative and γ-Cyclodextrin

更新日：2025/05/16

件数：7,237件

TOP

Japanese

No.1(全1件)

Improvement of the Solubility and Evaluation of the Physical Properties of an Inclusion Complex Formed by a New Ferulic Acid Derivative and γ-Cyclodextrin

このページを印刷

ID	JOS-acsomega.0c00277
著者：名前	池田, 奈央/井上, 裕/尾形, 由佳/村田, 勇/玄, 美燕/高山, 淳/坂本, 武史/岡崎, 真理/金本, 郁男
著者：別形式	Ikeda, Nao / Inoue, Yutaka / Ogata, Yuka / Murata, Isamu / Xuan, Meiyan / Takayama, Jun / Sakamoto, Takeshi / Okazaki, Mari / Kanamoto, Ikuo
著者：カナ	イケダ, ナオ/イノウエ, ユタカ/オガタ, ユカ/ムラタ, イサム/ゲン, ビエン/タカヤマ, ジュン/サカモト, タケシ/オカザキ, マリ/カナモト, イクオ
著者：所属	城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部
著者：所属(別形式）	Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Pharmaceutical Chemistry / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Pharmaceutical Chemistry / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Pharmaceutical Chemistry / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Pharmacology / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Drug Safety Management
著者版フラグ	publisher
出版地	Washington, DC
出版者	American Chemical Society
電子ISSN	24701343
掲載誌名	ACS Omega
巻	5
号	21
刊行年月	2020-06
開始ページ	12073
終了ページ	12080
コンテンツ作成日	2020-01-20
コンテンツ修正日	2020-05-06
コンテンツ登録日	2020-09-01
識別番号：DOI	info:doi/10.1021/acsomega.0c00277
識別番号：DOI（リンク）	https://doi.org/10.1021/acsomega.0c00277
PubMed番号	32548386
抄録	Ferulic acid derivative 012 (FAD012) is a ferulic acid (FA) derivative. The current study prepared a solid dispersion of FAD012 and γ-cyclodextrin (γCD) and ground it using a three-dimensional ball mill (3DGM) to prepare an inclusion complex. This study also assessed the physicochemical properties such as solubility of that complex. A Job’s plot indicated that FAD012 and γCD formed an inclusion complex at a molar ratio of 1:1. Phase solubility diagrams revealed that FAD012 produced a BS diagram. According to PXRD, FAD012 produced a diffraction peak at 2θ = 7.0° and γCD produced a diffraction peak at 2θ = 9.1°. Those two peaks were not produced by the 3DGM, but new peaks (2θ = 7.3 and 16.5°) were evident. DSC patterns revealed an endothermic peak due to the melting of FAD012 at 190 °C, but no endothermic peaks were evident with the 3DGM. NIR spectra of the 3DGM indicated that the methyl group of FAD012 produced a higher peak and that the OH groups of γCD produced a higher peak. 1H-1H ROESY NMR spectra (D2O) revealed cross peaks for protons of the methyl group of FAD012 and a proton (H-3) in the cavity of γCD, so FAD012 presumably interacts with the wide opening of the γCD torus. A solubility test (25 °C) indicated that solubility improved about 5-fold for the 3DGM in comparison to the solubility of FAD012 alone (about 140 μg/mL). Based on these findings, an FAD012/γCD complex was formed by cogrinding, and its solubility improved. These observations are expected to expand the usefulness of cogrinding of FAD012 with γCD using a 3D ball mill.
キーワード	FAD012/γ-cyclodextrin/solubility/three dementinal ball mill
注記	This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © 2020 American Chemical Society
このアイテムを表示する：本文(pdf)	ダウンロード回数：回
このアイテムを表示する：URI	https://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-acsomega.0c00277

var xurl =document.URL; var xrecid = 'G0000284repository_JOS-acsomega.0c00277'; var xReg = new RegExp(/(.*meta.*\/)/); var xmatch = xurl.match(xReg); var urlstr = RegExp.$1; if( xmatch) jQuery('a#infolib_permalink').html( urlstr + xrecid ); detailcont["max"] = '0'; detailcont["detailViewFlg"] = '0'; var xswitchViewButton = jQuery('div#detailContentsSwicher'); xswitchViewButton.show(); var xEditorButton = jQuery('div#detailEditor'); if( xEditorButton.length) { xpanel.xEditorPrime = "JOS-acsomega.0c00277"; xEditorButton.show(); } detailcont["contentsDspMax"] = '5'; detailcont["show"] = 'all'; detailcont["contentsDbId"] = 'G0000284repository'; detailcont["currentContNo"] = '0'; meta.detailSetViewerHeight();