城西大学機関リポジトリJURAEvaluation of Antibacterial Activity Expression of the Hinokitiol/Cyclodextrin Complex Against Bacteria

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Evaluation of Antibacterial Activity Expression of the Hinokitiol/Cyclodextrin Complex Against Bacteria

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ID	JOS-acsomega.0c03222
著者：名前	井上, 裕/鈴木, 莉奈/村田, 勇/野村, 陽恵/一色, 恭徳/金本, 郁男
著者：別形式	Inoue, Yutaka / Suzuki, Rina / Murata, Isamu / Nomura, Harue / Isshiki, Yasunori / Kanamoto, Ikuo
著者：カナ	イノウエ, ユタカ/スズキ, リナ/ムラタ, イサム/ノムラ, ハルエ/イッシキ, ヤスノリ/カナモト, イクオ
著者：所属	城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部
著者：所属(別形式）	Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Microbiology / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Microbiology / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Drug Safety Management
著者版フラグ	publisher
出版地	Washington, DC
出版者	American Chemical Society
電子ISSN	24701343
掲載誌名	ACS omega
巻	5
号	42
刊行年月	2020-10
開始ページ	27180
終了ページ	27187
コンテンツ作成日	2020-07-04
コンテンツ修正日	2020-10-06
コンテンツ登録日	2020-11-26
識別番号：DOI	info:doi/10.1021/acsomega.0c03222
識別番号：DOI（リンク）	https://doi.org/10.1021/acsomega.0c03222
抄録	The purpose of this study was to assess the antimicrobial activity of a solid dispersion prepared by mixing and grinding hinokitiol (HT) with α-cyclodextrin (αCD), βcyclodextrin (βCD), or γ-cyclodextrin (γCD). Antimicrobial activity was evaluated by calculating the minimum inhibitory concentration (MIC) and evaluating the change in the number of bacteria over time. The test microbes used were two Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus), two Gramnegative bacteria (Escherichia coli and Pseudomonas aeruginosa), and two fungi (Candida albicans and Aspergillus brasiliensis). Calculation of the MIC value of HT using the agar dilution method revealed that the MIC of HT/CD inclusion complexes was lower than that of HT alone. HT irreversibly inhibited the growth of microorganisms in a short amount of time. HT/CD complexes retained the antimicrobial activity of HT as a result of including HT in a CD complex. These results suggest that inclusion of HT, an antimicrobial component, using CDs could lead to appropriate control of the drug release rate and efficient display of antimicrobial activity.
キーワード	hinokitiol/cyclodextrin/ground mixture/antibacterial activity/antifungal activity
注記	This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License, which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © 2020 American Chemical Society
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このアイテムを表示する：URI	https://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-acsomega.0c03222

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