城西大学機関リポジトリJURAPreparation, Characterization, and In Vitro Evaluation of Inclusion Complexes Formed between S-Allylcysteine and Cyclodextrins

更新日：2024/12/25

件数：7,121件

TOP

Japanese

No.1(全1件)

Preparation, Characterization, and In Vitro Evaluation of Inclusion Complexes Formed between S-Allylcysteine and Cyclodextrins

このページを印刷

ID	JOS-acsomega.2c03489
著者：名前	立川, 吏乃/斎藤, 紘生/茂木, 肇/木村, 光利/北岸, 宏亮/Arce, Florencio Jr./See, Gerard Lee/谷川, 尚/井上, 裕
著者：別形式	Tachikawa, Rino / Saito, Hiroki / Moteki, Hajime / Kimura, Mitsutoshi / Kitagishi, Hiroaki / Arce, Florencio Jr. / See, Gerard Lee / Tanikawa, Takashi / Inoue, Yutaka
著者：カナ	タチカワ, リノ/サイトウ, ヒロキ/モテキ, ハジメ/キムラ, ミツトシ/キタギシ, ヒロアキ/Arce, Florencio Jr./See, Gerard Lee/タニカワ, タカシ/イノウエ, ユタカ
著者：所属	城西大学薬学部栄養治療学研究室 / 城西大学薬学部臨床薬理学研究室 / 城西大学薬学部臨床薬理学研究室 / 城西大学薬学部臨床薬理学研究室 / 同志社大学理工学部機能分子・生命化学科 / University of San Carlos, School of Health Care Professions, Department of Pharmacy, Pharmaceutical Research and Drug Development Laboratories / University of San Carlos, School of Health Care Professions, Department of Pharmacy, Pharmaceutical Research and Drug Development Laboratories / 城西大学薬学部栄養治療学研究室 / 城西大学薬学部栄養治療学研究室
著者：所属(別形式）	Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Nutri-Pharmacotherapeutics Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Clinical Pharmacology / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Clinical Pharmacology / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Clinical Pharmacology / Doshisha University, Faculty of Science and Engineering, Department of Molecular Chemistry and Biochemistry / University of San Carlos, School of Health Care Professions, Department of Pharmacy, Pharmaceutical Research and Drug Development Laboratories / University of San Carlos, School of Health Care Professions, Department of Pharmacy, Pharmaceutical Research and Drug Development Laboratories / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Nutri-Pharmacotherapeutics Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Nutri-Pharmacotherapeutics Management
著者版フラグ	publisher
出版地	Washington, DC
出版者	American Chemical Society
電子ISSN	24701343
掲載誌名	ACS Omega
巻	7
号	35
刊行年月	2022-08
開始ページ	31233
終了ページ	31245
コンテンツ作成日	2022-06-04
コンテンツ修正日	2022-08-10
コンテンツ登録日	2022-10-31
識別番号：DOI	info:doi/10.1021/acsomega.2c03489
識別番号：DOI（リンク）	https://doi.org/10.1021/acsomega.2c03489
抄録	The present study prepared inclusion complexes of S-allylcysteine (SAC) and cyclodextrin (α, β, γ) by the freeze-drying (FD) method and verified the inclusion behavior of the solid dispersion. Also, the study investigated the effect of SAC/CD complex formation on liver tumor cells. Isothermal titration calorimetry (ITC) measurements confirmed the exothermic titration curve for SAC/αCD, suggesting a molar ratio of SAC/αCD = 1/1, but no exothermic/endothermic reaction was obtained for the SAC/βCD and SAC/γCD system. Powder X-ray diffraction (PXRD) results showed that the characteristic diffraction peaks of SAC and CDs disappeared in FD (SAC/αCD) and FD (SAC/γCD), indicated by a halo pattern. On the other hand, diffraction peaks originating from SAC and βCDs were observed in FD (SAC/βCD). Near-infrared (NIR) absorption spectroscopy results showed that CH and OH groups derived from SAC and OH groups derived from αCD and γCD cavity were shifted, suggesting complex formation due to intermolecular interactions occurring in SAC/αCD and SAC/γCD. Stability test results showed that the stability was maintained with FD (SAC/αCD) over FD (SAC/βCD) and FD (SAC/γCD). In 1H–1H of NOESY NMR measurement, FD (SAC/αCD) was confirmed to have a cross peak at the CH group of the alkene of SAC and the proton (H-3, -5, -6) in the αCD cavity. In FD (SAC/γCD), a cross peak was confirmed at the alkyl group on the carbonyl group side of SAC and the proton (H-3) in the cavity of γCD. From the above, it was suggested that the inclusion mode of SAC is different on FD (SAC/CDs). The results of the hepatocyte proliferation inhibition test using HepG2 cells showed that FD (SAC/βCD) inhibited cell proliferation. On the other hand, FD (SAC/αCD) and FD (SAC/γCD) did not show a significant decrease in the number of viable cells. These results suggest that the difference in the inclusion mode may contribute to the stability and cell proliferation inhibition.
キーワード	S‑Allylcysteine/Cyclodextrins/Inclusion/Freeze Dried/HepG2
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © 2022 The Authors
このアイテムを表示する：本文(pdf)	( 5.7MB) ダウンロード回数：回
このアイテムを表示する：URI	https://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-acsomega.2c03489

var xurl =document.URL; var xrecid = 'G0000284repository_JOS-acsomega.2c03489'; var xReg = new RegExp(/(.*meta.*\/)/); var xmatch = xurl.match(xReg); var urlstr = RegExp.$1; if( xmatch) jQuery('a#infolib_permalink').html( urlstr + xrecid ); detailcont["max"] = '0'; detailcont["detailViewFlg"] = '0'; var xswitchViewButton = jQuery('div#detailContentsSwicher'); xswitchViewButton.show(); var xEditorButton = jQuery('div#detailEditor'); if( xEditorButton.length) { xpanel.xEditorPrime = "JOS-acsomega.2c03489"; xEditorButton.show(); } detailcont["contentsDspMax"] = '5'; detailcont["show"] = 'all'; detailcont["contentsDbId"] = 'G0000284repository'; detailcont["currentContNo"] = '0'; meta.detailSetViewerHeight();