| ID | JOS-anticanres.13929 |
| 著者：名前 | 高尾, 浩一/ 星, かおり/ 坂上, 宏/ Shi, Haixia/ 坂東, 健二郎/ 永井, 純子/ 植沢, 芳広/ 友村, 明人/ 友村, 美根子/ 杉田, 義昭 |
| 著者：別形式 | Takao, Koichi / Hoshi, Kaori / Sakagami, Hirshi / Shi, Haixia / Bandow, Kenjiro / Nagai, Junko / Uesawa, Yoshihiro / Tomomura, Akito / Tomomura, Mineko / Sugita, Yoshiaki |
| 著者：カナ | タカオ, コウイチ/ ホシ, カオリ/ サカガミ, ヒロシ/ Shi, Haixia/ バンドウ, ケンジロウ/ ナガイ, ジュンコ/ ウエサワ, ヨシヒロ/ トモムラ, アキト/ トモムラ, ミネコ/ スギタ, ヨシアキ |
| 著者：所属 | 城西大学薬学部薬科学科 / 城西大学薬学部薬科学科 / 明海大学歯科医学総合研究所 / Shanghai Jiatong University School of Medicine, Shanghai Ninth People’s Hospital / 明海大学歯学部生化学分野 / 明治薬科大学 / 明治薬科大学 / 明海大学歯学部生化学分野 / 明海大学健康科学部口腔保健学科 / 城西大学薬学部薬科学科 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences / Meikai University Research Institute of Odontology (M-RIO) / Shanghai Jiatong University School of Medicine, Shanghai Ninth People’s Hospital / Meikai University School of Dentistry, Division of Biochemistry / Meiji Pharmaceutical University, Department of Medical Molecular Informatics / Meiji Pharmaceutical University, Department of Medical Molecular Informatics / Meikai University School of Dentistry, Division of Biochemistry / Meikai University School of Sciences, Department of Oral Health Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences |
| 著者版フラグ | publisher |
| 出版地 | Highlands |
| 出版者 | International Institute of Anticancer Research |
| 冊子ISSN | 02507005 |
| 電子ISSN | 17917530 |
| 掲載誌名 | |
| 巻 | 40 |
| 号 | 1 |
| 刊行年月 | 2020-01 |
| 開始ページ | 87 |
| 終了ページ | 95 |
| コンテンツ作成日 | 2019-11-20 |
| コンテンツ修正日 | 2019-12-02 |
| コンテンツ登録日 | 2020-05-28 |
| 識別番号：DOI | info:doi/10.21873/anticanres.13929 |
| 識別番号：DOI（リンク） | |
| PubMed番号 | 31892556 |
| 抄録 | Background/Aim: Very few studies are available about the biological activity of 3-styrylchromones. Our previous study demonstrated the importance of methoxy group at 6-position of the chromone ring and hydroxyl group at 4’-position of phenyl group in styryl moiety. As a sequel of this study, we synthesized fourteen compounds that include eight 3-styrylchromones where methoxy group was introduced at 7-position of chromone rings, and then evaluated their tumor-specificity. Materials and Methods: Tumor-specificity (TS) was calculated by relative cytotoxicity against human oral squamous cell carcinoma cell lines versus human normal oral cells. Apoptosis induction and growth arrest were monitored by cell-cycle analysis. Quantitative structure–activity relationship analysis of TS was performed with 3,167 chemical descriptors. Results and Discussion: Two compounds, 7-methoxy-3-[(1E)-2-phenylethenyl]-4H-1-benzopyran-4-one [7] and 3-[(1E)-2-(4-hydroxyphenyl)ethenyl]-7-methoxy-4H-1-benzopyran-4-one [14] showed higher tumor-specificity than doxorubicin and 5-FU, suggesting the importance of methoxy group in 7-position of the chromone ring. These compounds induced the apoptosis and mitotic arrest in HSC-2 cells. The tumor-specificity of 3-styrylchromone derivatives were most correlated with descriptors for molecule shape and electronic charge. The present study suggested that modification by introducing methoxy group at 7-position, instead at 6-position, further increased the tumor-specificity of 3-styrylchromone. |
| キーワード | |
| 注記 | Publisher permission granted |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © 2020, International Institute of Anticancer Research (Dr. George J. Delinasios) |
| このアイテムを表示する：本文(pdf) |  ( 470.1KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
