ID | JOS-biom13111617 |
著者:名前 | |
著者:別形式 | Kimira, Yoshifumi / Osawa, Konosuke / Osawa, Yoshihiro / Mano, Hiroshi |
著者:カナ | |
著者:所属 | 城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 |
著者:所属(別形式) | Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Clinical Dietetics and Human Nutrition / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Clinical Dietetics and Human Nutrition / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Clinical Dietetics and Human Nutrition / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Clinical Dietetics and Human Nutrition |
著者版フラグ | publisher |
出版地 | Basel |
出版者 | MDPI |
電子ISSN | 2218273X |
掲載誌名 | |
巻 | 13 |
号 | 11 |
刊行年月 | 2023-11 |
開始ページ | 1 |
終了ページ | 12 |
コンテンツ作成日 | 2023-08-17 |
コンテンツ修正日 | 2023-11-03 |
コンテンツ登録日 | 2023-12-25 |
識別番号:DOI | info:doi/10.3390/biom13111617 |
識別番号:DOI(リンク) | |
PubMed番号 | 38002299 |
抄録 | Glucocorticoids, commonly used to manage inflammatory diseases, can induce muscle atrophy by accelerating the breakdown of muscle proteins. This research delves into the influence of Prolyl-hydroxyproline (Pro-Hyp), a collagen-derived peptide, on muscle atrophy induced with dexamethasone (DEX), a synthetic glucocorticoid, in mouse C2C12 skeletal myotubes. Exposure to DEX (10 μM) for 6 days resulted in a decrease in myotube diameter, along with elevated mRNA and protein levels of two muscle-atrophy-related ubiquitin ligases, muscle atrophy F-box (MAFbx, also known as atrogin-1) and muscle ring finger 1 (MuRF-1). Remarkably, treatment with 0.1 mM of Pro-Hyp mitigated the reduction in myotube thickness caused by DEX, while promoting the phosphorylation of Akt, mammalian target of rapamycin (mTOR), and forkhead box O3a (Foxo3a). This led to the inhibition of the upregulation of the ubiquitin ligases atrogin-1 and MuRF-1. These findings indicate the potential significance of Pro-Hyp as a promising therapeutic target for countering DEX-induced muscle atrophy. |
キーワード | |
注記 | Article number: 1617 (2023) Licensee MDPI, Basel, Switzerland.This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
言語 | eng |
資源タイプ | text |
ジャンル | |
フォーマット | application/pdf |
権利 | Copyright © 2023 by the authors. |
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