| ID | JOS-bmjopen-2012-002235 |
| 著者：名前 | |
| 著者：別形式 | Nakajima, Kei / Oshida, Haruki / Muneyuki, Toshitaka / Saito, Masafumi / Hori, Yumiko / Fuchigami, Hiroshi / Kakei, Masafumi / Munakata, Hiromi |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 / 自治医科大学医学部 / 城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 / 社会保険大宮総合病院 / 自治医科大学医学部 / 社会保険大宮総合病院 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmaceutical Sciences, Department of Medical Dietetics, Division of Clinical Nutrition / Josai University, Faculty of Pharmaceutical Sciences, Department of Medical Dietetics, Division of Clinical Nutrition / Jichi Medical University School of Medicine, Saitama Medical Center, First Department of Comprehensive Medicine / Josai University, Faculty of Pharmaceutical Sciences, Department of Medical Dietetics, Division of Clinical Nutrition / Josai University, Faculty of Pharmaceutical Sciences, Department of Medical Dietetics, Division of Clinical Nutrition / Social Insurance Omiya General Hospital, Department of Health Care Center / Jichi Medical University School of Medicine, Saitama Medical Center, First Department of Comprehensive Medicine / Social Insurance Omiya General Hospital, Department of Internal Medicine |
| 著者版フラグ | publisher |
| 出版者 | BMJ Publishing Group Ltd. |
| 掲載誌名 | |
| 巻 | 3 |
| 号 | 1 |
| 刊行年月 | 2013-01 |
| 開始ページ | 1 |
| 終了ページ | 8 |
| コンテンツ作成日 | 2013-01-03 |
| コンテンツ登録日 | 2013-01-03 |
| 識別番号：DOI | info:doi/10.1136/bmjopen-2012-002235 |
| 識別番号：DOI（リンク） | |
| PubMed番号 | info:pmid/23293250 |
| 抄録 | OBJECTIVES: Low serum amylase (LSA) was reported to be associated with obesity, metabolic syndrome (MetS) and diabetes. However, it is unknown as to whether LSA is associated with non-alcoholic fatty liver disease (NAFLD), a hepatic manifestation of MetS and insulin resistance. Therefore, we performed a clinical epidemiological study to investigate this potential association. DESIGN: A cross-sectional observational study with multivariate analysis. SETTING: Subjects were recruited in a healthcare centre in Saitama, an eastern district of Japan, near Tokyo. PARTICIPANTS: A total of 1475 asymptomatic adults aged 30-79 years who underwent detailed medical check-ups and who regularly consumed small amounts of alcohol (<20 g/day). OUTCOME MEASURES: Serum amylase, cardiometabolic risk factors, NAFLD determined by ultrasound, MetS determined by Adult Treatment Panel-III criteria and diabetes were assessed. RESULTS: The prevalence of NAFLD increased significantly from 22.5% to 42.4% (all grades) and from 9.2% to 24.0% (moderate or severe grade) from the highest to the lowest quartile of serum amylase. Multiple logistic regression analysis showed that, compared with the highest quartile of serum amylase, the lowest quartile of serum amylase was significantly associated with any-grade NAFLD and with moderate-to-severe NAFLD, even after adjusting for MetS or diabetes. The association between LSA and any-grade NAFLD disappeared after further adjustment for body mass index or waist circumference, whereas the association between LSA and moderate or severe NAFLD remained statistically significant (ORs (95%CI), 2.01 (1.07 to 3.78) and 2.06 (1.09 to 3.87), respectively, both p=0.01). CONCLUSIONS: Our results suggest that LSA may be associated with moderate or severe NAFLD in asymptomatic adults independent of MetS, diabetes and obesity. These results warrant confirmation in further studies. |
| キーワード | |
| 注記 | Free PMC Article. Open Access. |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| このアイテムを表示する：本文(pdf) |  ( 294.1KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
