城西大学機関リポジトリJURAOsteoclast Differentiation Is Suppressed by Increased O-GlcNAcylation Due to Thiamet G Treatment

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Osteoclast Differentiation Is Suppressed by Increased O-GlcNAcylation Due to Thiamet G Treatment

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ID	JOS-bpb.b20-00221
著者：名前	武内, 智春/堀本, 泰弘/大山, 翠/中谷, 祥恵/古旗, 賢二/田村, 真由美/荒田, 洋一郎/畑中, 朋美
著者：別形式	Takeuchi, Tomoharu / Horimoto, Yasuhiro / Oyama, Midori / Nakatani, Sachie / Kobata, Kenji / Tamura, Mayumi / Arata, Yoichiro / Hatanaka,Tomomi
著者：カナ	タケウチ, トモハル/ホリモト, ヤスヒロ/オオヤマ, ミドリ/ナカタニ, サチエ/コバタ, ケンジ/タムラ, マユミ/アラタ, ヨウイチロウ/ハタナカ,トモミ
著者：所属	城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 帝京大学薬学部 / 帝京大学薬学部 / 城西大学薬学部
著者：所属(別形式）	Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Teikyo University, Faculty of Pharma-Science / Teikyo University, Faculty of Pharma-Science / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences
著者版フラグ	publisher
出版地	東京
出版者	日本薬学会
出版者：カナ	ニホンヤクガクカイ
出版者：別名	The Pharmaceutical Society of Japan
NCID	AA10885497
冊子ISSN	09186158
電子ISSN	13475215
掲載誌名	Biological and Pharmaceutical Bulletin
巻	43
号	10
刊行年月	2020-10
開始ページ	1501
終了ページ	1505
コンテンツ作成日	2020-03-10
コンテンツ修正日	2020-07-05
コンテンツ登録日	2020-11-26
識別番号：DOI	info:doi/10.1248/bpb.b20-00221
識別番号：DOI（リンク）	https://doi.org/10.1248/bpb.b20-00221
抄録	Osteoclasts are the only bone-resorbing cells in organisms and understanding their differentiation mechanism is crucial for the treatment of osteoporosis. In the present study, we investigated the effect of Thiamet G, an O-GlcNAcase specific inhibitor, on osteoclastogenic differentiation. Thiamet G treatment increased global O-GlcNAcylation in murine RAW264 cells and suppressed receptor activator of nuclear factor-κB ligand (RANKL)-dependent formation in tartrate-resistant acid phosphatase (TRAP)-positive multinuclear cells, thereby suppressing the upregulation of osteoclast specific genes. Meanwhile, knockdown of O-linked N-acetylglucosamine (O-GlcNAc) transferase promoted the formation TRAP-positive multinuclear cells. Thiamet G treatment also suppressed RANKL and macrophage colony-stimulating factor (M-CSF) dependent osteoclast formation and bone-resorbing activity in mouse primary bone marrow cells and human peripheral blood mononuclear cells. These results indicate that the promotion of O-GlcNAc modification specifically suppresses osteoclast formation and its activity and suggest that chemicals affecting O-GlcNAc modification might potentially be useful in the prevention or treatment of osteoporosis in future.
キーワード	osteoclast/O-linked N-acetylglucosamine modification/differentiation/bone/Thiamet G
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © 2020 The Pharmaceutical Society of Japan
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このアイテムを表示する：URI	https://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-bpb.b20-00221

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