ID JOS-bpb.b20-00495
著者：名前 著者：別形式 Kurihara, Kazuki / Moteki, Hajime / Natsume, Hideshi / Ogihara, Masahiko / Kimura, Mitsutoshi
著者：カナ 著者：所属 城西大学薬学部薬学科臨床薬理学研究室 / 城西大学薬学部薬学科臨床薬理学研究室 / 城西大学薬学部薬学科製剤学研究室 / 城西大学薬学部薬学科臨床薬理学研究室 / 城西大学薬学部薬学科臨床薬理学研究室
著者：所属(別形式） Josai University, Faculty of Pharmaceutical Sciences, Department of Clinical Pharmacology / Josai University, Faculty of Pharmaceutical Sciences, Department of Clinical Pharmacology / Josai University, Faculty of Pharmaceutical Sciences, Department of Pharmaceutics / Josai University, Faculty of Pharmaceutical Sciences, Department of Clinical Pharmacology / Josai University, Faculty of Pharmaceutical Sciences, Department of Clinical Pharmacology
著者版フラグ publisher
出版地 東京
出版者 日本薬学会
出版者：カナ ニホンヤクガクカイ
出版者：別名 The Pharmaceutical Society of Japan
NCID AA10885497
冊子ISSN 09186158
電子ISSN 13475215
掲載誌名 巻 43
号 11
刊行年月 2020-11
開始ページ 1776
終了ページ 1784
コンテンツ作成日 2020-06-11
コンテンツ修正日 2020-08-21
コンテンツ登録日 2021-01-27
識別番号：DOI info:doi/10.1248/bpb.b20-00495
識別番号：DOI（リンク） NII論文ID 130007934081
抄録 Two-thirds partial hepatectomy (PHx) was performed in rats, and the differences in effects between S-allylcysteine (SAC) and other sulfur-containing compounds on regeneration of the remaining liver and restoration of the injury were examined. Three days after two-thirds PHx, rats treated with 300 mg/kg/d, per os (p.o.) SAC showed a 1.2-fold increase in liver weight per 100 g body weight compared with saline-treated controls. In contrast, S-methylcysteine (SMC) (300 mg/kg/d, p.o.) or cysteine (Cys) (300 mg/kg/d, p.o.) did not have a regeneration-promoting effect. In the comparison with control rats, the regenerating liver of SAC-treated rats showed a significantly higher 5-bromo-2′-deoxyuridine labeling index on day 1. In contrast, serum alanine aminotransferase activity, which increases following PHx, was significantly inhibited by SAC and SMC (but not Cys) on day 1 after two-thirds PHx. In addition, SAC induced increases in insulin-like growth factor (IGF)-1 and its receptor mRNA expressions at 1 h after two-thirds PHx, and it increased phosphorylation of extracellular signal-regulated kinase (ERK)2 and Akt at 3 h after two-thirds PHx without affecting serum growth hormone levels. These results demonstrate that SAC is a mitogenic effector of normal remnant liver and promotes recuperation of liver function after two-thirds PHx. Moreover, SAC-induced proliferative effects are mediated via increased mRNA expressions of IGF-1 and its receptor and subsequent phosphorylation of ERK2 and Akt.
キーワード 注記 UB05240020<Pre 医中誌>
言語 eng
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