| ID | JOS-chemengineering5030044 |
| 著者：名前 | |
| 著者：別形式 | Takayama, Rina / Ishizawa, Moe / Yamada, Miyuki / Inoue, Yutaka / Kanamoto, Ikuo |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部栄養治療学研究室 / 城西大学薬学部栄養治療学研究室 / 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部栄養治療学研究室 / 城西大学薬学部医薬品安全性学研究室 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Nutri-Pharmacotherapeutics Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Nutri-Pharmacotherapeutics Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Nutri-Pharmacotherapeutics Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Drug Safety Management |
| 著者版フラグ | publisher |
| 出版者 | MDPI |
| 電子ISSN | 23057084 |
| 掲載誌名 | |
| 巻 | 5 |
| 号 | 3 |
| 刊行年月 | 2021-08 |
| 開始ページ | 1 |
| 終了ページ | 17 |
| コンテンツ作成日 | 2021-06-21 |
| コンテンツ修正日 | 2021-07-27 |
| コンテンツ登録日 | 2021-09-21 |
| 識別番号：DOI | info:doi/10.3390/chemengineering5030044 |
| 識別番号：DOI（リンク） | |
| 抄録 | Soluplus (Sol) is an amphiphilic graft copolymer capable of forming self-assembled micelles and L-ascorbyl 2,6-dipalmitate (ASC-DP) aggregates spontaneously to form micelles. Micelles are used as drug carriers and can nanoparticulate drugs that are poorly soluble in water, such as minoxidil. The study aimed to prepare minoxidil-encapsulated nanoparticles using Sol/ASC-DP and evaluate their potential for targeted skin application. Sol/ASC-DP nanoparticles or Sol/ASC-DP with minoxidil were prepared using the hydration method, and physical evaluations were carried out, including assessments of particle size and zeta potential. Particle structure was evaluated by transmission electron microscopy (TEM) and 1H-nuclear magnetic resonance spectra to assess particle stability and perform functional evaluations in skin penetration tests. TEM images showed spherical micelle-like particles of approximately 100 nm for Sol/ASC-DP at a 9:1 ratio and of approximately 80 nm for Sol/ASC-DP with incorporated minoxidil at a 9:1:0.5 ratio. Changes were also observed in the solid state, suggesting a hydrophobic interaction between Sol and ASC-DP. In addition, evaporated microparticles (Sol/ASC-DP/minoxidil = 9/1/0.5) improved the skin permeability of minoxidil. These results suggest that Sol/ASC-DP nanoparticles form a stable new nanoparticle due to hydrophobic interactions, which would improve the skin permeability of minoxidil. |
| キーワード | |
| 注記 | Article number: 44 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © 2021 by the authors. |
| このアイテムを表示する：本文(pdf) |  ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
