| ID | JOS-chemengineering7020029 |
| 著者：名前 | |
| 著者：別形式 | Inoue, Yutaka / Nanri, Ayumi / Arce, Florencio Jr. / See, Gerard Lee / Tanikawa,Takashi / Yokogawa, Takami / Kitamura, Masashi |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部栄養治療学研究室 / 城西大学薬学部栄養治療学研究室 / University of San Carlos, School of Health Care Professions, Department of Pharmacy, Pharmaceutical Research and Drug Development Laboratories / University of San Carlos, School of Health Care Professions, Department of Pharmacy, Pharmaceutical Research and Drug Development Laboratories / 城西大学薬学部栄養治療学研究室 / 城西大学薬学部生薬学研究室 / 城西大学薬学部生薬学研究室 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Nutri-Pharmacotherapeutics Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Nutri-Pharmacotherapeutics Management / University of San Carlos, School of Health Care Professions, Department of Pharmacy, Pharmaceutical Research and Drug Development Laboratories / University of San Carlos, School of Health Care Professions, Department of Pharmacy, Pharmaceutical Research and Drug Development Laboratories / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Nutri-Pharmacotherapeutics Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Pharmacognosy / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Pharmacognosy |
| 著者版フラグ | publisher |
| 出版地 | Basel |
| 出版者 | MDPI |
| 電子ISSN | 23057084 |
| 掲載誌名 | |
| 巻 | 7 |
| 号 | 2 |
| 刊行年月 | 2023-03 |
| 開始ページ | 1 |
| 終了ページ | 12 |
| コンテンツ作成日 | 2023-03-02 |
| コンテンツ修正日 | 2023-03-27 |
| コンテンツ登録日 | 2023-05-31 |
| 識別番号：DOI | info:doi/10.3390/chemengineering7020029 |
| 識別番号：DOI（リンク） | |
| 抄録 | A three-component inclusion complex of ascorbyl palmitate (ASCP), urea (UR), and γ-cyclodextrin (γCD) with a molar ratio of 1/12 has been prepared for the first time using the evaporation method (EVP method) and the grinding and mixing method (GM method). Also, we investigated changes in the physicochemical properties of the three-component complexes. The powder X-ray diffraction (PXRD) measurements showed ASCP, UR, and γCD characteristic peaks in the physical mixture (PM) (AU (ASCP/UR = 1/12)/γCD = 1/2). In GM (AU (ASCP/UR = 1/12)/γCD = 1/1), new diffraction peaks were observed around 2θ = 7.5° and 16.6°, while characteristic peaks derived from EVP (ASCP/UR = 1/12) were observed at 2θ = 23.4° and 24.9°. On the other hand, new diffraction peaks at 2θ = 7.4° and 16.6° were observed in GM (1/2). In the differential scanning calorimeter (DSC) measurement, an endothermic peak at around 83 °C was observed in the GM (1/1) sample, which is thought to originate from the phase transition of urea from the hexagonal to the tetragonal form. An endothermic peak around 113.9 °C was also observed for EVP (ASCP/UR = 1/12). However, no characteristic phase transition-derived peak or EVP (ASCP/UR = 1/12)-derived endothermic peak was observed in GM (1/2). Near infrared (NIR) spectroscopy of GM (1/2) showed no shift in the peak derived from the CH group of ASCP. The peaks derived from the NH group of UR shifted to the high and low wavenumber sides at 5032 cm−1 and 5108 cm−1 in EVP (ASCP/UR = 1/12). The peak derived from the OH group of γCD shifted, and the peak derived from the OH group of ASCP broadened at GM (1/2). These results suggest that AU (ASCP/UR = 1/12)/γCD prepared by the mixed grinding method formed inclusion complexes at the molar ratio (1/2). |
| キーワード | |
| 注記 | p.12 Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © 2023 by the authors. |
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| このアイテムを表示する：URI | |
