| ID | JOS-cpb.39.458 |
| 著者:名前 | |
| 著者:別形式 | Endoh, Hirotaka / Kawaguchi, Takeo / Seki, Toshinobu / Hasegawa, Tetsuya / Juni, Kazuhiko |
| 著者:カナ | |
| 著者:所属 | 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 |
| 著者:所属(別形式) | Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences |
| 著者版フラグ | publisher |
| 出版地 | 東京 |
| 出版者 | 日本薬学会 |
| 出版者:カナ | ニホンヤクガクカイ |
| 出版者:別名 | The Pharmaceutical Society of Japan |
| NCID | AA00602100 |
| 冊子ISSN | 00092363 |
| 電子ISSN | 13475223 |
| 掲載誌名 | |
| 巻 | 39 |
| 号 | 2 |
| 刊行年月 | 1991-02 |
| 開始ページ | 458 |
| 終了ページ | 464 |
| コンテンツ作成日 | 1990-07-13 |
| コンテンツ登録日 | 2014-03-20 |
| 識別番号:DOI | info:doi/10.1248/cpb.39.458 |
| 識別番号:DOI(リンク) | |
| 識別番号:その他 | JOI:JST.Journalarchive/cpb1958/39.458 |
| 抄録 | Poly(L-lactic acid) (L-PLA) microspheres containing 5-fluoro-2'-deoxyuridine (FUdR) or its ester prodrugs with saturated aliphatic acids (FUdR-Cn, n=2, 3, 4, 5, 6, 8, 10 and 12) were prepared. The physicochemical and biological properties and antitumor activity of the L-PLA microspheres were studied. The lipophilicity of FUdR-Cn was increased by prolonging its acyl-promoieties. FUdR-C5, FUdR-C6, FUdR-C8, FUdR-C10 and FUdR-C12 showed almost complete incorporation into the microspheres, while incorporation of hydrophilic FUdR and FUdR-C2 was poor. The sustained release of FUdR from the microspheres containing FUdR-C4, FUdR-C5 and FUdR-C6 was obtained in the presence of esterase, and higher antitumor activity against P388 leukemia was observed in vivo. On the other hand, the release rates of FUdR from the microspheres containing FUdR-C10 and FUdR-C12 were very small, and their antitumor activity was much smaller than that of the free prodrug suspension. Effects of the susceptibility to enzymatic hydrolysis and the physicochemical properties of prodrugs on the release profiles of FUdR from spheres were discussed. |
| キーワード | |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright c The Pharmaceutical Society of Japan |
| このアイテムを表示する:本文(pdf) |  ( 1.0MB) ダウンロード回数: 回 |
| このアイテムを表示する:URI | |