| ID | JOS-cpb.c21-00131 |
| 著者：名前 | |
| 著者：別形式 | Sugibayashi, Kenji / Mika Futaki, / Miyu Hashimoto, / Fukuhara, Asuka / Matsumoto, Kengo / Oshizaka, Takeshi / Itakura, Shoko / Todo, Hiroaki |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西国際大学薬学部 / 城西大学薬学部 / 城西大学薬学部 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai International University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences |
| 著者版フラグ | publisher |
| 出版地 | 東京 |
| 出版者 | 日本薬学会 |
| 出版者：カナ | ニホンヤクガクカイ |
| 出版者：別名 | The Pharmaceutical Society of Japan |
| NCID | AA00602100 |
| 冊子ISSN | 00092363 |
| 電子ISSN | 13475223 |
| 掲載誌名 | |
| 巻 | 69 |
| 号 | 7 |
| 刊行年月 | 2021-07 |
| 開始ページ | 639 |
| 終了ページ | 645 |
| コンテンツ作成日 | 2021-02-11 |
| コンテンツ修正日 | 2021-04-12 |
| コンテンツ登録日 | 2022-02-24 |
| 識別番号：DOI | info:doi/10.1248/cpb.c21-00131 |
| 識別番号：DOI（リンク） | |
| PubMed番号 | 34193712 |
| 抄録 | The purpose of the present study was to evaluate whether iontophoresis (IP) accelerates the intradermal migration rate of medium molecular weight drugs. Sodium polystyrene sulfonate (PSA) and fluorescein isothiocyanate-dextran (FD) were used as model medium molecular weight acidic and non-electrolyte drugs, respectively. Low molecular weight acid and non-electrolyte drugs were also used for comparison. Drug-loaded excised split-layered skin (SL skin) was used in the experiment. SL skin was prepared using (i) whole skin was split once, (ii) the drug solution was applied on the lower skin, and (iii) the upper skin was layered onto the lower skin containing the drug solution as in the original skin. The effect of constant-current cathodal or anodal IP was applied to the SL skin, and the time course of the cumulative amount of drug migration from the SL skin through the dermis to the receiver was followed. In cases without IP and with anodal IP, the intradermal migration rates of medium molecular weight drugs were much lower than those of small molecules. The driving force for drug migration was thought to be simple diffusion through the skin layer. In contrast, cathodal IP significantly increased the intradermal migration rate of PSA not but of FD or low molecular weight drugs. This IP-facilitated migration of PSA was probably due to electrorepulsion. These results suggest that IP can be used to increase the intradermal migration of medium molecular weight charged drugs. |
| キーワード | |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © 2021 The Pharmaceutical Society of Japan |
| このアイテムを表示する：本文(pdf) |  ( 631.6KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
