ID | JOS-cpb.c21-00181 |
著者:名前 | |
著者:別形式 | Abe, Akinari / Suzuki, Hiromichi / Amagai, Sayaka / Saito, Miyuki / Itakura, Shoko / Todo, Hiroaki / Sugibayashi, Kenji |
著者:カナ | |
著者:所属 | 城西大学大学院薬学研究科 / 城西大学大学院薬学研究科 / 城西大学大学院薬学研究科 / 城西大学大学院薬学研究科 / 城西大学大学院薬学研究科 / 城西大学大学院薬学研究科 / 城西大学大学院薬学研究科 |
著者:所属(別形式) | Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Graduate School of Pharmaceutical Sciences |
著者版フラグ | publisher |
出版地 | 東京 |
出版者 | 日本薬学会 |
出版者:カナ | ニホンヤクガクカイ |
出版者:別名 | The Pharmaceutical Society of Japan |
NCID | AA00602100 |
冊子ISSN | 00092363 |
電子ISSN | 13475223 |
掲載誌名 | |
巻 | 69 |
号 | 8 |
刊行年月 | 2021-08 |
開始ページ | 806 |
終了ページ | 810 |
コンテンツ作成日 | 2021-02-26 |
コンテンツ修正日 | 2021-04-26 |
コンテンツ登録日 | 2021-09-21 |
識別番号:DOI | info:doi/10.1248/cpb.c21-00181 |
識別番号:DOI(リンク) | |
PubMed番号 | 34334526 |
NII論文ID | 130008070256 |
抄録 | Effect of rubbing application on the skin permeation of a hydrophilic drug caffeine (CAF) and lipophilic drug rhododendrol (RD) from lotion and cream were investigated. Skin permeation of CAF was markedly
increased by rubbing action independent of the formulation type. In addition, the skin penetration-enhancement effect was affected by the rubbing direction: rubbing application against the direction of hair growth showed the highest permeation compared with rubbing applications along the direction of hair growth and in a circular pattern on the skin. On the other hand, no enhancement effect was observed by the rubbing actions on the skin permeation of RD, regardless of formulation type. Change in the infundibula orifice size of hair follicles by the rubbing and following skin stretching may be related to the higher skin permeation for CAF. In contrast, high RD distribution into the stratum corneum may be a reason why no enhancement effect was observed by the rubbing action. These results can be helpful to predict safety and effectiveness of topically applied formulations. |
キーワード | |
言語 | eng |
資源タイプ | text |
ジャンル | |
フォーマット | application/pdf |
権利 | Copyright © 2021 The Pharmaceutical Society of Japan |
このアイテムを表示する:本文(pdf) | ( 487.6KB) ダウンロード回数: 回 |
このアイテムを表示する:URI | |