ID JOS-etm.2019.8230
著者:名前 著者:別形式 Murata, Isamu / Imanari, Mayuki / Komiya, Marise / Kobayashi, Jun / Inoue, Yutaka / Kanamoto, Ikuo
著者:カナ 著者:所属 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医療栄養学科 / 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医薬品安全性学研究室 /
著者:所属(別形式) Josai University, Faculty of Pharmacy and Pharmaceutical Science, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmacy and Pharmaceutical Science, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmacy and Pharmaceutical Science, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmacy and Pharmaceutical Science, Division of Pathophysiology, Department of Clinical Dietetics and Human Nutrition / Josai University, Faculty of Pharmacy and Pharmaceutical Science, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmacy and Pharmaceutical Science, Laboratory of Drug Safety Management
著者版フラグ publisher
出版者 Spandidos Publications
冊子ISSN 17920981
電子ISSN 17921015
掲載誌名 巻 19
号 1
刊行年月 2019-11
開始ページ 777
終了ページ 785
コンテンツ作成日 2019-01-07
コンテンツ修正日 2019-05-08
コンテンツ登録日 2020-07-21
識別番号:DOI info:doi/10.3892/etm.2019.8230
識別番号:DOI(リンク) PubMed番号 31853328
抄録 Crush syndrome (CS), a serious medical condition, which is characterized by damage to myocytes due to pressure and is associated with high mortality, even when patients receive fluid therapy. Icing therapy over the affected muscle has been reported to be effective in improving mitochondrial dysfunction and inflammation. These effects are thought to be secondary to improvements in the leakage of potassium and myoglobin from the damaged myocytes in the early stages of disease. However, their effects on the various symptoms of CS are unclear. It was hypothesized that treatment with icing will inhibit the influence of potassium by vasoconstriction, exert anti-inflammatory effects in the affected myocytes and improve mitochondrial function The CS model constructed by subjecting anesthetized rats to bilateral hindlimb compression with a rubber tourniquet for 5 h. The rats were then randomly divided into six groups: i) Sham; ii) CS without treatment (CS); iii) and iv) icing for 30 or 180 min over the entire hindlimb on CS rats (CI-30 and -180), respectively; and v) and vi) local icing for 30 or 180 min over the affected area on CS rats (CLI-30 and -180), respectively. Under continuous monitoring and recording of arterial blood pressures, blood and tissue samples were collected for biochemical analyses at designated time points prior to and following reperfusion. The survival rate, vital signs, and blood gas parameters in the CS group were lethal compared with the sham group. These were also improved in the CI-30 and CLI-30 groups compared with the CS group; however, they worsened in the CI-180 and CLI-180 groups due to hypothermia. The CI-30 and CLI-30 groups demonstrated tendencies of improvements compared with the CS group. Systemic inflammation and mitochondria dysfunction had improved in these groups compared with the CS group. We suggest icing therapy to temporarily prolong the viability after crush injury. Its effectiveness can be improved by combining it with other infusion therapies.
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