ID JOS-etm.2022.11249
著者:名前 著者:別形式 Murata, Isamu / Sugai, Tsugumi / Murakawa, Yumiko / Miyamoto, Yoshiaki / Kobayashi, Jun / Inoue, Yutaka / Kanamoto, Ikuo
著者:カナ 著者:所属 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部薬物治療学研究室 / 城西大学薬学部病態生理学研究室 / 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医薬品安全性学研究室
著者:所属(別形式) Josai University, Faculty of Pharmacy and Pharmaceutical Science, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmacy and Pharmaceutical Science, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmacy and Pharmaceutical Science, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmacy and Pharmaceutical Science, Laboratory of Pharmacotherapeutics and Neuropsychopharmacology / Josai University, Faculty of Pharmacy and Pharmaceutical Science, Laboratory of Pathophysiology / Josai University, Faculty of Pharmacy and Pharmaceutical Science, Laboratory of Drug Safety Management /Josai University, Faculty of Pharmacy and Pharmaceutical Science, Laboratory of Drug Safety Management
著者版フラグ publisher
出版地 Athens
出版者 Spandidos Publications
NCID AA12610820
冊子ISSN 17920981
電子ISSN 17921015
掲載誌名 巻 23
号 5
刊行年月 2022-05
開始ページ 1
終了ページ 13
コンテンツ作成日 2021-07-28
コンテンツ修正日 2022-01-21
コンテンツ登録日 2022-12-24
識別番号:DOI info:doi/10.3892/etm.2022.11249
識別番号:DOI(リンク) 抄録 Crush syndrome (CS) is a potentially lethal condition characterized by muscle cell damage resulting from decompression following compression. Patients with CS can develop cardiac failure, kidney dysfunction, shock, systemic inflammation and sepsis. Salvianolic acid B (SalB) has cardiac and kidney protective effects and anti‑oxidative, anti‑inflammatory, anti‑apoptotic and anti‑bacterial properties. The present study aimed to demonstrate the survival benefit of SalB in the CS rat model, which comprised anesthetized rats with bilateral hindlimb compression by a rubber tourniquet for 5 h. The rats examined were randomly divided into four groups: i) Sham; ii) sham treated with SalB; iii) CS rat model without treatment; and iv) CS rat model treated with SalB. Under continuous monitoring and recording of arterial blood pressures, blood and tissue samples were collected for biochemical analyses at designated timepoints before and after reperfusion. SalB administration improved the survival rate, kidney function (by treating shock and metabolic acidosis) and inflammation (by reducing mitochondrial dysfunction and endothelial damage). Reduced incidence of cardiac failure due to hyperkalemia was associated with reduced muscle injury via the prevention of mitochondrial dysfunction. Additionally, indirect antibacterial action by the neutrophil extracellular trap system (NETs) was observed. SalB administration to the CS rat model led to a substantial improvement in survival following CS by decreasing kidney and cardiac dysfunctions, inflammation, and endothelial dysfunction by improving the mitochondrial function and through antibacterial effects via NETs.
キーワード 注記 p.13 Article Number: 320
言語 eng
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