ID JOS-ijms23062931
著者：名前 著者：別形式 Sonoda, Kunihiro / Kono, Yuka / Kitamori, Kazuya / Ohtake, Kazuo / Shiba, Sachiko / Kasono, Keizo / Kobayashi, Jun
著者：カナ 著者：所属 金城学院大学生活環境学部食環境栄養学科 / 金城学院大学生活環境学部食環境栄養学科 / 金城学院大学生活環境学部食環境栄養学科 / 城西大学薬学部薬学科生理学研究室 / 城西大学薬学部薬学科生理学研究室 / 城西大学薬学部薬学科生理学研究室 /城西大学薬学部医療栄養学科病態生理学
著者：所属(別形式） Kinjo Gakuin University, College of Human Life and Environment, Department of Food and Nutritional Environment / Kinjo Gakuin University, College of Human Life and Environment, Department of Food and Nutritional Environment / Kinjo Gakuin University, College of Human Life and Environment, Department of Food and Nutritional Environment / Josai University, Faculty of Pharmaceutical Science, School of Pharmaceutical Sciences, Division of Physiology / Josai University, Faculty of Pharmaceutical Science, School of Pharmaceutical Sciences, Division of Physiology / Josai University, Faculty of Pharmaceutical Science, School of Pharmaceutical Sciences, Division of Physiology / Josai University, Faculty of Pharmaceutical Science, Department of Clinical Dietetics and Human Nutrition, Division of Pathophysiology
著者版フラグ publisher
出版地 Basel
出版者 MDPI
冊子ISSN 16616596
電子ISSN 14220067
掲載誌名 巻 23
号 6
刊行年月 2022-03
開始ページ 1
終了ページ 16
コンテンツ作成日 2022-02-05
コンテンツ修正日 2022-03-07
コンテンツ登録日 2023-02-15
識別番号：DOI info:doi/10.3390/ijms23062931
識別番号：DOI（リンク） PubMed番号 35328352
抄録 Nonalcoholic steatohepatitis (NASH) is a chronic liver disease that leads to liver cirrhosis and hepatocellular carcinoma. Endothelial dysfunction caused by hepatic lipotoxicity is an underlying NASH pathology observed in the liver and the cardiovascular system. Here, we evaluated the effect of dietary nitrite on a rat NASH model. Stroke-prone, spontaneously hypertensive 5/Dmcr rats were fed a high-fat/high-cholesterol diet to develop the NASH model, with nitrite or captopril (100 mg/L, each) supplementation in drinking water for 8 weeks. The effects of nitrite and captopril were evaluated using immunohistochemical analyses of the liver and heart tissues. Dietary nitrite suppressed liver fibrosis in the rats by reducing oxidative stress, as measured using the protein levels of nicotinamide adenine dinucleotide phosphate oxidase components and inflammatory cell accumulation in the liver. Nitrite lowered the blood pressure in hypertensive NASH rats and suppressed left ventricular chamber enlargement. Similar therapeutic effects were observed in a captopril-treated rat NASH model, suggesting the possibility of a common signaling pathway through which nitrite and captopril improve NASH pathology. In conclusion, dietary nitrite attenuates the development of NASH with cardiovascular involvement in rats and provides an alternative NASH therapeutic strategy.
キーワード 注記 p.16 Article number: 2931 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
言語 eng
資源タイプ text
ジャンル フォーマット application/pdf
権利 Copyright © 2022 by the authors.
このアイテムを表示する：本文(pdf) ダウンロード回数：
回
このアイテムを表示する：URI 
