城西大学機関リポジトリJURASpermine Suppresses Adipocyte Differentiation and Exerts Anti-Obesity Effects In Vitro and In Vivo

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Spermine Suppresses Adipocyte Differentiation and Exerts Anti-Obesity Effects In Vitro and In Vivo

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ID	JOS-ijms231911818
著者：名前	中谷, 祥恵/堀本, 泰弘/中林, なつみ/唐澤, 麻由美/和田, 政裕/古旗, 賢二
著者：別形式	Nakatani, Sachie / Horimoto, Yasuhiro / Nakabayashi, Natsumi / Karasawa, Mayumi / Wada, Masahiro / Kobata, Kenji
著者：カナ	ナカタニ, サチエ/ホリモト, ヤスヒロ/ナカバヤシ, ナツミ/カラサワ, マユミ/ワダ, マサヒロ/コバタ, ケンジ
著者：所属	城西大学大学院薬学研究科 / 城西大学大学院薬学研究科 / 城西大学大学院薬学研究科 / 城西大学大学院薬学研究科 / 城西大学大学院薬学研究科 / 城西大学大学院薬学研究科
著者：所属(別形式）	Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Graduate School of Pharmaceutical Sciences
著者版フラグ	publisher
出版地	Basel
出版者	MDPI
冊子ISSN	16616596
電子ISSN	14220067
掲載誌名	International Journal of Molecular Sciences
巻	23
号	19
刊行年月	2022-10
開始ページ	1
終了ページ	8
コンテンツ作成日	2022-08-31
コンテンツ修正日	2022-09-27
コンテンツ登録日	2022-12-24
識別番号：DOI	info:doi/10.3390/ijms231911818
識別番号：DOI（リンク）	https://doi.org/10.3390/ijms231911818
PubMed番号	36233120
抄録	Endogenous polyamines such as putrescine (Put), spermidine (Spd), and spermine (Spm) affect adipocyte differentiation. In this study, we investigated the effect of exogenously supplemented polyamines on mouse adipocyte differentiation and anti-obesity actions in vitro and in vivo. The preadipocyte cell line, 3T3-L1, was cultured with Put, Spd, or Spm, and lipid accumulation in the cells was measured by Oil Red O staining. Lipid accumulation was significantly suppressed by Spm. Suppression of CCAAT/enhancer binding protein α mRNA by Spm suggested that the decreased lipid accumulation was due to delaying the cell differentiation. The body weight and fat of obese mice induced with a high-fat diet were reduced by oral ingestion of Spm. In conclusion, oral supplementation of Spm has the ability to prevent obesity through inhibition of adipocyte differentiation.
キーワード	polyamine/spermine/differentiation/adipocyte/obesity/ポリアミン/スペルミン/分化/脂肪細胞/肥満
注記	p.8 Article number: 11818 Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © 2022 by the authors.
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