城西大学機関リポジトリJURACurcumae Longae Rhizoma and Saussureae Radix Inhibit Nitric Oxide Production and Cannabinoid Receptor 2 Down-regulation

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Curcumae Longae Rhizoma and Saussureae Radix Inhibit Nitric Oxide Production and Cannabinoid Receptor 2 Down-regulation

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ID	JOS-invivo.12695
著者：名前	谷川, 尚/北村, 雅史/林, 康広/横川, 貴美/井上, 裕
著者：別形式	Tanikawa, Takashi / Kitamura, Masashi / Hayashi, Yasuhiro / Yokogawa, Takami / Inoue, Yutaka
著者：カナ	タニカワ, タカシ/キタムラ, マサシ/ハヤシ, ヤスヒロ/ヨコガワ, タカミ/イノウエ, ユタカ
著者：所属	城西大学薬学部薬学科栄養治療学研究室 / 城西大学薬学部薬学科生薬学研究室 / 帝京大学薬学部生物化学研究室 / 城西大学薬学部薬学科生薬学研究室 / 城西大学薬学部薬学科栄養治療学研究室
著者：所属(別形式）	Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, School of Pharmacy, Laboratory of Nutri-Pharmacotherapeutics Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, School of Pharmacy, Laboratory of Pharmacognocy / Teikyo University, Faculty of Pharma-Science, Laboratory of Biological Chemistry / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, School of Pharmacy, Laboratory of Pharmacognocy / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, School of Pharmacy, Laboratory of Nutri-Pharmacotherapeutics Management
著者版フラグ	publisher
出版者	International Institute of Anticancer Research
冊子ISSN	0258851X
電子ISSN	17917549
掲載誌名	In Vivo
巻	36
号	1
刊行年月	2022-01
開始ページ	227
終了ページ	232
コンテンツ作成日	2021-10-16
コンテンツ修正日	2021-11-16
コンテンツ登録日	2022-02-14
識別番号：DOI	info:doi/10.21873/invivo.12695
識別番号：DOI（リンク）	https://doi.org/10.21873/invivo.12695
PubMed番号	34972719
抄録	Background/Aim: The cannabinoid 2 (CB2) receptor is an important regulator of immunoinflammatory responses. Crude drugs commonly used in Japanese traditional Kampo medicine have displayed anti-inflammatory effects; however, few studies have reported that these effects are mediated via CB2 receptor signaling. Therefore, this study aimed to elucidate CB2 receptor-related anti-inflammatory regulation in crude drugs. Materials and Methods: The ethanol extracts of 34 crude drugs listed in the Japanese Pharmacopeia were tested, and the inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production were evaluated in murine macrophage RAW 264 cells. Results: The extracts of Curcumae Longae Rhizoma (dried rhizome of Curcuma longa) and Saussureae Radix (dried root of Saussurea lappa) significantly inhibited NO production and attenuated the LPS-induced decrease in CB2 receptor mRNA expression.Conclusion: Curcumae Longae Rhizoma and Saussureae Radix can modulate the CB2-receptor-related anti-inflammatory regulation in macrophages.
キーワード	Curcumae Longae Rhizoma/Saussureae Radix/nitric oxide/TLR4/CB2/RAW 264 cells
注記	This article is freely accessible online.
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios)
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このアイテムを表示する：URI	https://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-invivo.12695

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