ID | JOS-invivo.13117 |
著者:名前 | |
著者:別形式 | Tanikawa, Takashi / Kitamura, Masashi / Hayashi, Yasuhiro / Tomida, Natsumi / Uwaya, Akemi / Isami, Fumiyuki / Yokogawa, Takami / Inoue, Yutaka |
著者:カナ | |
著者:所属 | 城西大学薬学部薬学科栄養治療学研究室 / 城西大学薬学部薬学科生薬学研究室 / 宮崎大学農学部海洋資源創薬研究室 / Newage, Inc., Research and Development / Newage, Inc., Research and Development / Newage, Inc., Research and Development / 城西大学薬学部薬学科生薬学研究室 / 城西大学薬学部薬学科栄養治療学研究室 |
著者:所属(別形式) | Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, School of Pharmacy, Laboratory of Nutri-Pharmacotherapeutics Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, School of Pharmacy, Laboratory of Pharmacognosy / University of Miyazaki, Faculty of Agriculture, Laboratory of Marine Resources for Drug Discovery / Newage, Inc., Research and Development / Newage, Inc., Research and Development / Newage, Inc., Research and Development / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, School of Pharmacy, Laboratory of Pharmacognosy / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, School of Pharmacy, Laboratory of Nutri-Pharmacotherapeutics Management |
著者版フラグ | publisher |
出版地 | Kapandriti |
出版者 | International Institute of Anticancer Research (IIAR) |
冊子ISSN | 0258851X |
電子ISSN | 17917549 |
掲載誌名 | |
巻 | 37 |
号 | 2 |
刊行年月 | 2023-03 |
開始ページ | 591 |
終了ページ | 595 |
コンテンツ作成日 | 2022-12-27 |
コンテンツ修正日 | 2023-01-25 |
コンテンツ登録日 | 2023-05-31 |
識別番号:DOI | info:doi/10.21873/invivo.13117 |
識別番号:DOI(リンク) | |
PubMed番号 | 36881078 |
抄録 | Background/Aim: The inflammatory response plays an important role in the activation and progression of many inflammation-related diseases. Cannabis sativa and Morinda citrifolia have long been used in folk medicine to treat inflammation. Cannabidiol is the most abundant non-psychoactive phytocannabinoid in C. sativa and exhibits anti-inflammatory activity. The objective of this study was to examine the anti-inflammatory effect of cannabidiol in combination with M. citrifolia and compare its effects with those of cannabidiol alone. Materials and Methods: RAW264 cells stimulated with lipopolysaccharide (200 ng/ml) were treated with cannabidiol (0-10 μM), M. citrifolia seed extract (0-100 μg/ml), or a combination of both for 8 or 24 h. Following the treatments, nitric oxide production in the activated RAW264 cells and the expression of inducible nitric oxide synthase were assessed. Results: Our results showed that combination of cannabidiol (2.5 μM) and M. citrifolia seed extract (100 μg/ml) exhibited more efficient inhibition of nitric oxide production than cannabidiol treatment alone in lipopolysaccharide-stimulated RAW264 cells. The combination treatment also reduced the expression of inducible nitric oxide synthase. Conclusion: These results suggest that the anti-inflammatory effect of combined treatment with cannabidiol and M. citrifolia seed extract causes a reduction in the expression of inflammatory mediators. |
キーワード | |
注記 | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license (https://creativecommons.org/licenses/by-nc-nd/4.0). |
言語 | eng |
資源タイプ | text |
ジャンル | |
フォーマット | application/pdf |
権利 | Copyright © 2023, International Institute of Anticancer Research (Dr. George J. Delinasios) |
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このアイテムを表示する:URI | |