| ID | JOS-j.bmcl.2021.127845 |
| 著者:名前 | |
| 著者:別形式 | Kamauchi, Hitoshi / Kimura, Yu / Ushiwatari, Mikoto / Suzuki, Mitsuaki / Seki,Taishi / Takao, Koichi / Sugita, Yoshiaki |
| 著者:カナ | |
| 著者:所属 | 城西大学薬学部薬科学科 / 城西大学薬学部薬科学科 / 城西大学薬学部薬学科 / 城西大学理学部化学科 /城西大学薬学部薬科学科 / 城西大学薬学部薬科学科 / 城西大学薬学部薬学科 |
| 著者:所属(別形式) | Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences / Josai University, Faculty of Science, Department of Chemistry / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences |
| 著者版フラグ | author |
| 出版者 | Elsevier |
| 冊子ISSN | 0960894X |
| 掲載誌名 | |
| 巻 | 37 |
| 刊行年月 | 2021-04 |
| 開始ページ | 1 |
| 終了ページ | 6 |
| コンテンツ作成日 | 2020-11-09 |
| コンテンツ修正日 | 2021-01-29 |
| コンテンツ登録日 | 2023-09-29 |
| 識別番号:DOI | info:doi/10.1016/j.bmcl.2021.127845 |
| 識別番号:DOI(リンク) | |
| PubMed番号 | 33571649 |
| 抄録 | Thirty-five pyridone derivatives were synthesized, with derivatization conducted on polycyclic pyridone scaffolds, including cis- or trans-oxydecalin and other cyclic structures, by domino-Knoevenagel-electrocyclic reactions. The anti-fungal activities of the synthesized compounds were tested against Candida albicans. Ten compounds inhibited hyphal formation without inhibiting growth. Pyridones with anti-hyphal formation activity (4c, 6d, 12a and 12c) were tested for their ability to inhibit biofilm formation. Compound 6d showed both anti-hyphal and biofilm inhibition activity. |
| キーワード | |
| 注記 | Article No.127845 |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © 2021 Elsevier B.V. |
| このアイテムを表示する:本文(pdf) |  ダウンロード回数: 回 |
| このアイテムを表示する:URI | |