| ID | JOS-j.ejps.2021.106096 |
| 著者：名前 | |
| 著者：別形式 | Ono, Naoto / Iibuchi, Tomoya / Todo, Hiroaki / Itakura, Shoko / Adachi, Hirotoshi / Sugibayashi, Kenji |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / PassPort Technologies, Inc. / 城西大学薬学部 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / PassPort Technologies, Inc. / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences |
| 著者版フラグ | publisher |
| 出版地 | Netherlands |
| 出版者 | Elsevier B.V. |
| 冊子ISSN | 09280987 |
| 電子ISSN | 18790720 |
| 掲載誌名 | |
| 巻 | 170 |
| 刊行年月 | 2022-03 |
| 開始ページ | 1 |
| 終了ページ | 8 |
| コンテンツ作成日 | 2021-08-10 |
| コンテンツ修正日 | 2021-12-09 |
| コンテンツ登録日 | 2022-03-30 |
| 識別番号：DOI | info:doi/10.1016/j.ejps.2021.106096 |
| 識別番号：DOI（リンク） | |
| PubMed番号 | 34929301 |
| 抄録 | Thermalporation has gained attention as a physical means to enhance skin permeation by creating micropores in the primary skin barrier, stratum corneum, which allows much higher permeation of middle and high molecular weight biopharmaceuticals. In the present study, a PassPort® system (PS) was used as a thermalporation device, and the obtained change in permeation resistance of drugs was evaluated using a parallel skin permeation-resistance model. In addition, the blood concentration-time profile after topical application of insulin was also investigated with the PS treatment. Fluorescein isothiocyanate-dextran (FD-4) and insulin were used as model middle molecular weight drugs. Micropores created by the PS treatment were measured using an optical microscope. An in vitro skin permeation and an in vivo pharmacokinetics experiments were done with FD-4 and insulin, respectively. Barrier function recovery after the PS treatment was evaluated with changes in the electrical skin resistance. About 960-fold higher skin permeation of FD-4 was observed by PSs treatment (4 milliseconds (ms), 200 micropores/cm2). A gradually increased blood concentration of insulin was observed by the PSs treatment, and the relative bioavailability of insulin was 21.1% compared with subcutaneous injection. Skin resistance value was dramatically decreased immediately after the PS treatment, but its value was turned into the initial one by 12 h. The thermalporation is effective for improving skin permeation of FD-4 and transdermal absorption of insulin. These results suggested that the PS treatment may be utilized to increase the skin permeation of topically applied FD-4 and insulin. |
| キーワード | |
| 注記 | 8p. Article No.106096 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © 2021 The Authors. |
| このアイテムを表示する：本文(pdf) |  ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
